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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002472%21RIV12-MZ0-00023001
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients, an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was found for non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fat in liver-transplants patients between protocol biopsies and for the screening of steatosis in other liver diseases. Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients, an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was found for non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fat in liver-transplants patients between protocol biopsies and for the screening of steatosis in other liver diseases.
dcterms:title
MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients
skos:prefLabel
MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients
skos:notation
RIV/00023001:_____/11:00002472!RIV12-MZ0-00023001
n7:predkladatel
n8:ico%3A00023001
n3:aktivita
n5:Z n5:P
n3:aktivity
P(NS9707), P(NT11238), Z(MZ0IKEM2005)
n3:cisloPeriodika
5
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n6:9828648 n6:4319443 n6:6665160 n6:8891699 n6:6325823 n6:7395973 n6:9546340
n3:druhVysledku
n18:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
214130
n3:idVysledku
RIV/00023001:_____/11:00002472
n3:jazykVysledku
n15:eng
n3:klicovaSlova
biopsy; lipids; liver steatosis; liver transplantation; magnetic resonance spectroscopy
n3:klicoveSlovo
n9:liver%20steatosis n9:magnetic%20resonance%20spectroscopy n9:liver%20transplantation n9:lipids n9:biopsy
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[71392683B5F9]
n3:nazevZdroje
Magnetic resonance materials in physics, biology and medicine
n3:obor
n17:FJ
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n14:NS9707 n14:NT11238
n3:rokUplatneniVysledku
n13:2011
n3:svazekPeriodika
24
n3:tvurceVysledku
Trunečka, Pavel Hejlová, Irena Dezortová, Monika Wagnerová, Dita Voska, Luděk Škoch, Antonín Hájek, Milan
n3:wos
000295177400005
n3:zamer
n19:MZ0IKEM2005
s:issn
0968-5243
s:numberOfPages
8
n11:doi
10.1007/s10334-011-0264-9