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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002450%21RIV12-MZ0-00023001
rdf:type
skos:Concept n13:Vysledek
dcterms:description
The aim of this study was to confirm or refute the difference between efficacy of long-term specific immunotherapy (SIT) with standardized allergen vaccine consisting of six grass pollens (oat grass, orchard grass, fescue, rye grass, timothy grass, and rye) administered either by sublingual or by supralingual route. To investigate clinical and immunologic changes, 51 patients of a previous 1-year double-blind, placebo-controlled, randomized study were enrolled in an open randomized study that continued over the next 3 years. Sublingual or supralingual immunotherapy (SLIT) was performed in the same way, keeping the drops under or on the tongue, respectively, for 1-2 minutes before swallowing them. Data about symptoms scores and rescue medication intake during grass pollen seasons, as well as skin-prick test results, levels of specific IgG, and IgE antibodies were collected after each pollen season. It was clearly shown that both routes of administration were effective, leading to a significant decrease of clinical symptoms of grass pollen allergy after SIT lasting 3-4 years. No statistically significant difference between sublingually and supralingually treated patients was observed at the end of the study. Adverse effects were limited to a small number of generally mild local and/or systemic reactions with no significant difference between both administration ways of SIT. The significant therapeutic effect of both SLIT and supralingual immunotherapy lasting 3-4 years was clearly achieved. Despite no significant difference between efficacy of both administration ways of SIT, the onset of sublingual SIT effect seems to be slightly faster than that of supralingual SIT. The aim of this study was to confirm or refute the difference between efficacy of long-term specific immunotherapy (SIT) with standardized allergen vaccine consisting of six grass pollens (oat grass, orchard grass, fescue, rye grass, timothy grass, and rye) administered either by sublingual or by supralingual route. To investigate clinical and immunologic changes, 51 patients of a previous 1-year double-blind, placebo-controlled, randomized study were enrolled in an open randomized study that continued over the next 3 years. Sublingual or supralingual immunotherapy (SLIT) was performed in the same way, keeping the drops under or on the tongue, respectively, for 1-2 minutes before swallowing them. Data about symptoms scores and rescue medication intake during grass pollen seasons, as well as skin-prick test results, levels of specific IgG, and IgE antibodies were collected after each pollen season. It was clearly shown that both routes of administration were effective, leading to a significant decrease of clinical symptoms of grass pollen allergy after SIT lasting 3-4 years. No statistically significant difference between sublingually and supralingually treated patients was observed at the end of the study. Adverse effects were limited to a small number of generally mild local and/or systemic reactions with no significant difference between both administration ways of SIT. The significant therapeutic effect of both SLIT and supralingual immunotherapy lasting 3-4 years was clearly achieved. Despite no significant difference between efficacy of both administration ways of SIT, the onset of sublingual SIT effect seems to be slightly faster than that of supralingual SIT.
dcterms:title
Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy
skos:prefLabel
Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy
skos:notation
RIV/00023001:_____/11:00002450!RIV12-MZ0-00023001
n13:predkladatel
n17:ico%3A00023001
n5:aktivita
n16:V n16:Z
n5:aktivity
V, Z(MSM0021620812)
n5:cisloPeriodika
2
n5:dodaniDat
n9:2012
n5:domaciTvurceVysledku
n8:3776956
n5:druhVysledku
n12:J
n5:duvernostUdaju
n14:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
188656
n5:idVysledku
RIV/00023001:_____/11:00002450
n5:jazykVysledku
n11:eng
n5:klicovaSlova
placebo-dontrolled trial; standardized 5-grass-pollen extract; double-blind; swallow immunotherapy; clinical-trials; pollen extract; efficacy; rhinoconjunctivitis; rhinitis; mechanism
n5:klicoveSlovo
n7:clinical-trials n7:rhinitis n7:standardized%205-grass-pollen%20extract n7:rhinoconjunctivitis n7:mechanism n7:efficacy n7:pollen%20extract n7:double-blind n7:placebo-dontrolled%20trial n7:swallow%20immunotherapy
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[377AD8A74CD6]
n5:nazevZdroje
Allergy and asthma proceedings
n5:obor
n6:EC
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:rokUplatneniVysledku
n9:2011
n5:svazekPeriodika
32
n5:tvurceVysledku
Králová Lesná, Ivana Petráš, M. Sýkora, T. Panzner, P. Liška, M.
n5:wos
000289321100009
n5:zamer
n18:MSM0021620812
s:issn
1088-5412
s:numberOfPages
9
n10:doi
10.2500/aap.2011.32.3423