This HTML5 document contains 53 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/domain/vavai/projekt/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n6http://linked.opendata.cz/resource/domain/vavai/subjekt/
n5http://linked.opendata.cz/ontology/domain/vavai/
n10http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023001%3A_____%2F11%3A00002440%21RIV12-MZ0-00023001/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n11http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002440%21RIV12-MZ0-00023001
rdf:type
skos:Concept n5:Vysledek
dcterms:description
In some patients, heart failure (HF) is associated with increased pulmonary vascular resistance (PVR). The magnitude and the reversibility of PVR elevation affect the HF management. Sildenafil has been recently recognized as potent PVR-lowering drug in HF. The aim of the study was to compare hemodynamic effects and pulmonary selectivity of sildenafil to prostaglandin E1 (PGE1). Right-heart catheterization was performed in 13 euvolemic advanced HF patients with elevated PVR (6.3?2 Wood´s units). Hemodynamic parameters were measured at the baseline, during i.v. infusion of PGE1 (alprostadil 200 ng?kg-1?min-1) and after 40 mg oral dose of sildenafil. Both drugs similarly reduced systemic vascular resistance (SVR), but sildenafil had higher effect on PVR (?28 % vs. ?49 %, p=0.05) and transpulmonary pressure gradient than PGE1. The PVR/SVR ratio ? an index of pulmonary selectivity, did not change after PGE1 (p=0.7) but it decreased by ?32 % (p=0.004) after sildenafil. Both drugs similarly reduced pulmonary artery mean and wedge pressures and increased cardiac index (+27 % and +28 %). Sildenafil led more often to transplant-acceptable PVR while causing smaller drop of mean systemic pressure than PGE1. In conclusion, vasodilatatory effects of sildenafil in patients with heart failure are more pronounced in pulmonary than in systemic circulation. In some patients, heart failure (HF) is associated with increased pulmonary vascular resistance (PVR). The magnitude and the reversibility of PVR elevation affect the HF management. Sildenafil has been recently recognized as potent PVR-lowering drug in HF. The aim of the study was to compare hemodynamic effects and pulmonary selectivity of sildenafil to prostaglandin E1 (PGE1). Right-heart catheterization was performed in 13 euvolemic advanced HF patients with elevated PVR (6.3?2 Wood´s units). Hemodynamic parameters were measured at the baseline, during i.v. infusion of PGE1 (alprostadil 200 ng?kg-1?min-1) and after 40 mg oral dose of sildenafil. Both drugs similarly reduced systemic vascular resistance (SVR), but sildenafil had higher effect on PVR (?28 % vs. ?49 %, p=0.05) and transpulmonary pressure gradient than PGE1. The PVR/SVR ratio ? an index of pulmonary selectivity, did not change after PGE1 (p=0.7) but it decreased by ?32 % (p=0.004) after sildenafil. Both drugs similarly reduced pulmonary artery mean and wedge pressures and increased cardiac index (+27 % and +28 %). Sildenafil led more often to transplant-acceptable PVR while causing smaller drop of mean systemic pressure than PGE1. In conclusion, vasodilatatory effects of sildenafil in patients with heart failure are more pronounced in pulmonary than in systemic circulation.
dcterms:title
Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure
skos:prefLabel
Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure
skos:notation
RIV/00023001:_____/11:00002440!RIV12-MZ0-00023001
n5:predkladatel
n6:ico%3A00023001
n3:aktivita
n13:Z n13:P
n3:aktivity
P(GA305/09/1390), P(NS10497), Z(MZ0IKEM2005)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n12:6807437 n12:5510155 n12:9540628 n12:3750744 n12:1236105 n12:4066332
n3:druhVysledku
n16:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
229235
n3:idVysledku
RIV/00023001:_____/11:00002440
n3:jazykVysledku
n17:eng
n3:klicovaSlova
heart failure; pulmonary vascular resistance; hemodynamics; sildenafil; prostaglandin E1
n3:klicoveSlovo
n9:pulmonary%20vascular%20resistance n9:prostaglandin%20E1 n9:hemodynamics n9:sildenafil n9:heart%20failure
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[0D208E0E3EC4]
n3:nazevZdroje
Physiological research
n3:obor
n19:FA
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n14:GA305%2F09%2F1390 n14:NS10497
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
60
n3:tvurceVysledku
Kettner, Jiří Al-Hiti, Hikmet Málek, Ivan Kautzner, Josef Melenovský, Vojtěch Syrovátka, Petr
n3:wos
000291154900013
n3:zamer
n10:MZ0IKEM2005
s:issn
0862-8408
s:numberOfPages
6