This HTML5 document contains 44 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/domain/vavai/projekt/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/resource/domain/vavai/subjekt/
n10http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n11http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023001%3A_____%2F11%3A00002415%21RIV12-MZ0-00023001/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002415%21RIV12-MZ0-00023001
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Diabetic nephropathy (DN), the most serious complication of Type 1 diabetes (DM1), has a strong genetic component. Cyclooxygenase-2 (COX-2), an inducible enzyme by a number of stimuli, has been implicated in pathophysiology of cardiovascular and renal disease, including DN. The allele -765C, of the -765G>C polymorphism (rs20417) in the COX-2 promoter has lower promoter activity compared with the -765G allele and protective effects in cardiovascular disease. This polymorphism was not investigated in patients with DM1 and nephropathy. The study was conducted in 779 Caucasian patients with DM1 and compared to a representative sample of healthy Czech population. The patients demonstrated lower frequencies of the CC genotype (P=0.005). From the DM1 cohort, 153 patients met the criteria for low risk of the development of DN (LRDN, duration of DM1>10 years, normoalbuminuria, normotension) and 139 patients had manifest DN. There were no differences in -765G>C polymorphisms between LRDN and DN patients. Moreover, the C/G allele frequencies did not also differ between the groups. In conclusion, patients with DM1 display lower freqencies of the protective CC genotype as compared to healthy subjects. However, the study did not reveal associations of -765G>C polymorphism with the risk of DN. Diabetic nephropathy (DN), the most serious complication of Type 1 diabetes (DM1), has a strong genetic component. Cyclooxygenase-2 (COX-2), an inducible enzyme by a number of stimuli, has been implicated in pathophysiology of cardiovascular and renal disease, including DN. The allele -765C, of the -765G>C polymorphism (rs20417) in the COX-2 promoter has lower promoter activity compared with the -765G allele and protective effects in cardiovascular disease. This polymorphism was not investigated in patients with DM1 and nephropathy. The study was conducted in 779 Caucasian patients with DM1 and compared to a representative sample of healthy Czech population. The patients demonstrated lower frequencies of the CC genotype (P=0.005). From the DM1 cohort, 153 patients met the criteria for low risk of the development of DN (LRDN, duration of DM1>10 years, normoalbuminuria, normotension) and 139 patients had manifest DN. There were no differences in -765G>C polymorphisms between LRDN and DN patients. Moreover, the C/G allele frequencies did not also differ between the groups. In conclusion, patients with DM1 display lower freqencies of the protective CC genotype as compared to healthy subjects. However, the study did not reveal associations of -765G>C polymorphism with the risk of DN.
dcterms:title
A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy
skos:prefLabel
A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy
skos:notation
RIV/00023001:_____/11:00002415!RIV12-MZ0-00023001
n10:predkladatel
n15:ico%3A00023001
n3:aktivita
n17:P
n3:aktivity
P(NR9368)
n3:cisloPeriodika
2
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n12:6873472 n12:4104501 n12:6513832 n12:3791882
n3:druhVysledku
n18:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
184059
n3:idVysledku
RIV/00023001:_____/11:00002415
n3:jazykVysledku
n9:eng
n3:klicovaSlova
cyclooxygenase-2; diabetic nephropathy; -765G>C polymorphism
n3:klicoveSlovo
n7:-765G%3EC%20polymorphism n7:cyclooxygenase-2 n7:diabetic%20nephropathy
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[FD960D021453]
n3:nazevZdroje
Physiological research
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n13:NR9368
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
60
n3:tvurceVysledku
Komers, Radko Hubáček, Jaroslav Lánská, Věra Pelikánová, Terezie
n3:wos
000291154900021
s:issn
0862-8408
s:numberOfPages
4