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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F10%3A00002388%21RIV11-MZ0-00023001
rdf:type
skos:Concept n14:Vysledek
dcterms:description
This study was designed to test the role of liver lipases in the degradation of liver triacylglycerols (TAG) and to determine the effect of dietary induced TAG accumulation in the liver on regulation of their lipolysis. Male Wistar rats were administered high-fat or high-sucrose diet for two weeks. Individual lipases (HL; TGH; LAL) were identified according to their different pH optimum. Administration of both diets resulted in liver TAG accumulation (HFD >>> HSD). The only lipase capable to hydrolyse intracellular TAG was LAL. On standard diet, LAL activity towards both endogenous and exogenous substrates was up-regulated in fasting and down-regulated in fed state. The intensity of autophagy determined according to the LC3-II/LC3-I protein ratio followed a similar pattern. HFD led to an increase of this ratio, elevation of LAL activity in phagolysosomal fraction and abolishment of fasting/fed-dependent differences. LAL activity significantly correlated with ketogenesis in all groups (r = 0.8 This study was designed to test the role of liver lipases in the degradation of liver triacylglycerols (TAG) and to determine the effect of dietary induced TAG accumulation in the liver on regulation of their lipolysis. Male Wistar rats were administered high-fat or high-sucrose diet for two weeks. Individual lipases (HL; TGH; LAL) were identified according to their different pH optimum. Administration of both diets resulted in liver TAG accumulation (HFD >>> HSD). The only lipase capable to hydrolyse intracellular TAG was LAL. On standard diet, LAL activity towards both endogenous and exogenous substrates was up-regulated in fasting and down-regulated in fed state. The intensity of autophagy determined according to the LC3-II/LC3-I protein ratio followed a similar pattern. HFD led to an increase of this ratio, elevation of LAL activity in phagolysosomal fraction and abolishment of fasting/fed-dependent differences. LAL activity significantly correlated with ketogenesis in all groups (r = 0.8
dcterms:title
The autophagy-lysosomal pathway is involved in TAG degradation in the liver: the effect of high-sucrose and high-fat diet The autophagy-lysosomal pathway is involved in TAG degradation in the liver: the effect of high-sucrose and high-fat diet
skos:prefLabel
The autophagy-lysosomal pathway is involved in TAG degradation in the liver: the effect of high-sucrose and high-fat diet The autophagy-lysosomal pathway is involved in TAG degradation in the liver: the effect of high-sucrose and high-fat diet
skos:notation
RIV/00023001:_____/10:00002388!RIV11-MZ0-00023001
n3:aktivita
n8:Z n8:P
n3:aktivity
P(NS9696), Z(MZ0IKEM2005)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n6:3989399 n6:9662898 n6:9460322 n6:3973425 n6:6337953
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
248258
n3:idVysledku
RIV/00023001:_____/10:00002388
n3:jazykVysledku
n17:eng
n3:klicovaSlova
lysosomal lipase; high-fat diet; high-sucrose diet; steatosis; rat
n3:klicoveSlovo
n4:steatosis n4:high-fat%20diet n4:high-sucrose%20diet n4:rat n4:lysosomal%20lipase
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[56CC52AA4657]
n3:nazevZdroje
Folia biologica (Praha)
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n15:NS9696
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
56
n3:tvurceVysledku
Páleníčková, Eliška Kazdová, Ludmila Daňková, Helena Papáčková, Zuzana Cahová, Monika
n3:wos
000281924500005
n3:zamer
n18:MZ0IKEM2005
s:issn
0015-5500
s:numberOfPages
10