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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F10%3A00002336%21RIV11-MZ0-00023001
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Uterine fibroid or leiomyoma is a frequent non-malignant tumour with unknown aetiology and pathogenesis. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (<= 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for developme Uterine fibroid or leiomyoma is a frequent non-malignant tumour with unknown aetiology and pathogenesis. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (<= 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for developme
dcterms:title
Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid
skos:prefLabel
Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid
skos:notation
RIV/00023001:_____/10:00002336!RIV11-MZ0-00023001
n3:aktivita
n11:V n11:N
n3:aktivity
N, V
n3:cisloPeriodika
5
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n7:3456013 n7:6829449 n7:8498598 n7:7194641
n3:druhVysledku
n15:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
292874
n3:idVysledku
RIV/00023001:_____/10:00002336
n3:jazykVysledku
n4:eng
n3:klicovaSlova
uterine fibroid; myoma; cytokine; gene polymorphism
n3:klicoveSlovo
n6:uterine%20fibroid n6:cytokine n6:myoma n6:gene%20polymorphism
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[A0132A9C999E]
n3:nazevZdroje
Folia biologica (Praha)
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
56
n3:tvurceVysledku
Sosna, O. Stříž, Ilja Kolesár, Libor Kužel, D. Fait, T. Slavčev, Antonij Skibová, Jelena Mara, M.
n3:wos
000284254900003
s:issn
0015-5500
s:numberOfPages
5