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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F10%3A00002296%21RIV11-MZ0-00023001
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1 Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1
dcterms:title
The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness
skos:prefLabel
The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness
skos:notation
RIV/00023001:_____/10:00002296!RIV11-MZ0-00023001
n3:aktivita
n17:P
n3:aktivity
P(NR9333)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n12:8395489
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
264381
n3:idVysledku
RIV/00023001:_____/10:00002296
n3:jazykVysledku
n15:eng
n3:klicovaSlova
pulse wave velocity; nitric oxide synthase; T786C; G894T; polymorphism; smoking
n3:klicoveSlovo
n4:T786C n4:smoking n4:polymorphism n4:pulse%20wave%20velocity n4:nitric%20oxide%20synthase n4:G894T
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D9B482121F03]
n3:nazevZdroje
Physiological Research
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n6:NR9333
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Šimon, J. Cífková, Renata Pešta, M. Mayer, O. Filipovský, J. Dolejšová, M.
n3:wos
000282054700006
s:issn
0862-8408
s:numberOfPages
8