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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F10%3A00002200%21RIV11-MZ0-00023001
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Although atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice, precise mechanisms that lead to the onset and persistence of AF have not completely been elucidated. Over the last decade, outstanding progress has been made in understanding the complex pathophysiology of AF. The key role of ectopic foci in pulmonary veins as a trigger of AF has been recognized. Furthermore, structural remodeling was identified as the main mechanism for AF persistence, confirming predominant role of atrial fibrosis. Systemic inflammatory state, oxidative stress injury, autonomic balance and neurohormonal activation were discerned as important modifiers that affect AF susceptibility. This new understanding of AF pathophysiology has led to the emergence of novel therapies. Ablative interventions, renin-angiotensin system blockade, modulation of oxidative stress and targeting tissue fibrosis represent new approaches in tackling AF. This review aims to provide a brief summary of novel insights Although atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice, precise mechanisms that lead to the onset and persistence of AF have not completely been elucidated. Over the last decade, outstanding progress has been made in understanding the complex pathophysiology of AF. The key role of ectopic foci in pulmonary veins as a trigger of AF has been recognized. Furthermore, structural remodeling was identified as the main mechanism for AF persistence, confirming predominant role of atrial fibrosis. Systemic inflammatory state, oxidative stress injury, autonomic balance and neurohormonal activation were discerned as important modifiers that affect AF susceptibility. This new understanding of AF pathophysiology has led to the emergence of novel therapies. Ablative interventions, renin-angiotensin system blockade, modulation of oxidative stress and targeting tissue fibrosis represent new approaches in tackling AF. This review aims to provide a brief summary of novel insights
dcterms:title
New insights into mechanisms of atrial fibrillation New insights into mechanisms of atrial fibrillation
skos:prefLabel
New insights into mechanisms of atrial fibrillation New insights into mechanisms of atrial fibrillation
skos:notation
RIV/00023001:_____/10:00002200!RIV11-MZ0-00023001
n3:aktivita
n13:Z
n3:aktivity
Z(MZ0IKEM2005)
n3:cisloPeriodika
1
n3:dodaniDat
n6:2011
n3:domaciTvurceVysledku
n7:1476068 n7:9467920 n7:6807437 n7:4066332
n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
274695
n3:idVysledku
RIV/00023001:_____/10:00002200
n3:jazykVysledku
n17:eng
n3:klicovaSlova
atrial fibrillation; triggers; Electrical remodeling; Structural remodeling; Fibrosis
n3:klicoveSlovo
n4:Structural%20remodeling n4:triggers n4:Electrical%20remodeling n4:Fibrosis n4:atrial%20fibrillation
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[4930034C0FE2]
n3:nazevZdroje
Physiological Research
n3:obor
n16:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Aldhoon, Bashar Melenovský, Vojtěch Kautzner, Josef Peichl, Petr
n3:wos
000276097000002
n3:zamer
n14:MZ0IKEM2005
s:issn
0862-8408
s:numberOfPages
13