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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F10%3A00002190%21RIV11-MZ0-00023001
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas
dcterms:title
Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis
skos:prefLabel
Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis
skos:notation
RIV/00023001:_____/10:00002190!RIV11-MZ0-00023001
n3:aktivita
n11:P n11:Z
n3:aktivity
P(IAA500110604), P(NR9359), P(NR9387), P(NS9696), Z(AV0Z50110509)
n3:cisloPeriodika
1-2
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n7:3626792 n7:6009662 n7:3973425 n7:7882092
n3:druhVysledku
n6:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
263367
n3:idVysledku
RIV/00023001:_____/10:00002190
n3:jazykVysledku
n15:eng
n3:klicovaSlova
steatohepatitis; trangenic rats; SREBP-1a; dyslipidemia; PUFA
n3:klicoveSlovo
n5:dyslipidemia n5:trangenic%20rats n5:SREBP-1a n5:PUFA n5:steatohepatitis
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[CABA9FF10DB8]
n3:nazevZdroje
Molecular and cellular biochemistry
n3:obor
n9:FB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
9
n3:projekt
n10:NR9359 n10:NR9387 n10:IAA500110604 n10:NS9696
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
335
n3:tvurceVysledku
Malínská, Hana Oliyarnyk, Olena Landa, V. Šimáková, M. Zídek, V. Hubová, Miriam Mlejnek, P. Pravenec, M. Kazdová, Ludmila
n3:wos
000273812100014
n3:zamer
n4:AV0Z50110509
s:issn
0300-8177
s:numberOfPages
7