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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F09%3A00002769%21RIV12-MZ0-00023001
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000218101&Ausgabe=248012&ProduktNr=223841&filename=000218101.pdf
dcterms:description
Background: Pulmonary endarterectomy (PEA) is an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). The present study tested the hypothesis that inflammation, as determined by circulating cytokine levels, may contribute to the difficulty in controlling arterial blood pressure after PEA. Materials and Methods: Thirty-six patients with CTEPH (22 males and 14 females) underwent PEA using cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest. Plasma concentrations of tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-6 and IL-8 were measured repeatedly in arterial blood samples. Results: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB. Furthermore, a significant correlation was found between the cardiac index (CI) and both IL-6 and IL-8 at the separation from CPB. Conclusions: Hemodynamic instability after PEA has been associated with higher postoperative plasma concentrations of IL-6 and IL-8. The positive relation between inflammatory cytokines and CI, or cytokines and vasopressor support, is in accordance with the hypothesis that cytokine activation may be among the neurohumoral factors responsible for cardiodepression and systemic vasoplegia in CTEPH patients undergoing PEA. Background: Pulmonary endarterectomy (PEA) is an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). The present study tested the hypothesis that inflammation, as determined by circulating cytokine levels, may contribute to the difficulty in controlling arterial blood pressure after PEA. Materials and Methods: Thirty-six patients with CTEPH (22 males and 14 females) underwent PEA using cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest. Plasma concentrations of tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-6 and IL-8 were measured repeatedly in arterial blood samples. Results: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB. Furthermore, a significant correlation was found between the cardiac index (CI) and both IL-6 and IL-8 at the separation from CPB. Conclusions: Hemodynamic instability after PEA has been associated with higher postoperative plasma concentrations of IL-6 and IL-8. The positive relation between inflammatory cytokines and CI, or cytokines and vasopressor support, is in accordance with the hypothesis that cytokine activation may be among the neurohumoral factors responsible for cardiodepression and systemic vasoplegia in CTEPH patients undergoing PEA.
dcterms:title
Hemodynamic instability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension correlates with cytokine network hyperstimulation Hemodynamic instability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension correlates with cytokine network hyperstimulation
skos:prefLabel
Hemodynamic instability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension correlates with cytokine network hyperstimulation Hemodynamic instability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension correlates with cytokine network hyperstimulation
skos:notation
RIV/00023001:_____/09:00002769!RIV12-MZ0-00023001
n3:aktivita
n11:P n11:V
n3:aktivity
P(NR9224), V
n3:cisloPeriodika
1
n3:dodaniDat
n9:2012
n3:domaciTvurceVysledku
n19:5279208
n3:druhVysledku
n5:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
316982
n3:idVysledku
RIV/00023001:_____/09:00002769
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Hemodynamic instability; Pulmonary endarterectomy; Chronic thromboembolic pulmonary hypertension
n3:klicoveSlovo
n4:Chronic%20thromboembolic%20pulmonary%20hypertension n4:Hemodynamic%20instability n4:Pulmonary%20endarterectomy
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[2B5493DE7C28]
n3:nazevZdroje
European surgical research
n3:obor
n16:FJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:projekt
n8:NR9224
n3:rokUplatneniVysledku
n9:2009
n3:svazekPeriodika
43
n3:tvurceVysledku
Zakharchenko, M. Linhart, A. Lindner, J. Jansa, P. Gürlich, Robert Kunstyr, J. Kubzova, K. Maruna, P.
n3:wos
000266572500007
s:issn
0014-312X
s:numberOfPages
8
n18:doi
10.1159/000218101