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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F09%3A00002757%21RIV12-MZ0-00023001
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/elan.200804431/abstract;jsessionid=9EAFB81212824ABC1DE31FA6DF6DE902.d02t01
dcterms:description
The main aim of this paper is to study interaction between strontium and metallothionein (MT), and to determine changes in strontium and thiols (MT, reduced glutathione, cysteine, and homocysteine) level in plasma, serum, and urine samples of patients treated with strontium ranelate (SrR). To investigate the interactions between MT and strontium(II) ions, adsorptive transfer stripping technique coupled with differential pulse voltammetry (DPV) the Brdicka reaction was employed. Besides standard Brdicka signals (Co, RS(2)Co, Cat1, Cat2, Cat3), we observed new signal related to Sr-MT interaction. Further we investigated the effect of various time of interaction, concentration of strontium(II) ions and temperature of supporting electrolyte on Brdicka signals. Optimal time of interaction was 240 s. Under temperature of supporting electrolyte 20 degrees C, we measured linear dependence of Cat3 signal height on strontium(II) ions concentration. After that we have investigated the possibility of strontium-MT interactions, we were interested in strontium, MT and low molecular mass thiols levels in serum and urine of patients treated with strontium(II) ions to cure osteoporosis. Strontium concentration determined by atomic absorption spectrometry was 55 +/- 5 mu g/L before and 10,500 +/- 1,400 mu g/L at the 30(th) day of SrR administration. Levels of metallothionein in serum ranged from 0.1 to 6.4 mu M. Correlation between serum strontium concentration and MT level was determined and correlation coefficient was R = 0.93. The main aim of this paper is to study interaction between strontium and metallothionein (MT), and to determine changes in strontium and thiols (MT, reduced glutathione, cysteine, and homocysteine) level in plasma, serum, and urine samples of patients treated with strontium ranelate (SrR). To investigate the interactions between MT and strontium(II) ions, adsorptive transfer stripping technique coupled with differential pulse voltammetry (DPV) the Brdicka reaction was employed. Besides standard Brdicka signals (Co, RS(2)Co, Cat1, Cat2, Cat3), we observed new signal related to Sr-MT interaction. Further we investigated the effect of various time of interaction, concentration of strontium(II) ions and temperature of supporting electrolyte on Brdicka signals. Optimal time of interaction was 240 s. Under temperature of supporting electrolyte 20 degrees C, we measured linear dependence of Cat3 signal height on strontium(II) ions concentration. After that we have investigated the possibility of strontium-MT interactions, we were interested in strontium, MT and low molecular mass thiols levels in serum and urine of patients treated with strontium(II) ions to cure osteoporosis. Strontium concentration determined by atomic absorption spectrometry was 55 +/- 5 mu g/L before and 10,500 +/- 1,400 mu g/L at the 30(th) day of SrR administration. Levels of metallothionein in serum ranged from 0.1 to 6.4 mu M. Correlation between serum strontium concentration and MT level was determined and correlation coefficient was R = 0.93.
dcterms:title
Electrochemical investigation of strontium-metallothionein interactions-analysis of serum and urine of patients with osteoporosis Electrochemical investigation of strontium-metallothionein interactions-analysis of serum and urine of patients with osteoporosis
skos:prefLabel
Electrochemical investigation of strontium-metallothionein interactions-analysis of serum and urine of patients with osteoporosis Electrochemical investigation of strontium-metallothionein interactions-analysis of serum and urine of patients with osteoporosis
skos:notation
RIV/00023001:_____/09:00002757!RIV12-MZ0-00023001
n3:aktivita
n11:S n11:P n11:V
n3:aktivity
P(IAA401990701), S, V
n3:cisloPeriodika
3-5
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n8:2691280
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
312814
n3:idVysledku
RIV/00023001:_____/09:00002757
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Strontium; Metallothionein; Differential pulse voltammetry; Brdicka reaction; Heavy metal-protein interaction; Osteoporosis; Human blood serum and urine
n3:klicoveSlovo
n5:Human%20blood%20serum%20and%20urine n5:Strontium n5:Brdicka%20reaction n5:Osteoporosis n5:Metallothionein n5:Differential%20pulse%20voltammetry n5:Heavy%20metal-protein%20interaction
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5CE4282CA704]
n3:nazevZdroje
Electroanalysis
n3:obor
n19:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n16:IAA401990701
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
21
n3:tvurceVysledku
Vajtr, David Adam, Vojtěch Prusa, Richard Baloun, Jiří Fabrik, Ivo Kizek, Rene Kukacka, Jiří Sotorník, Ivo Babula, Petr
n3:wos
000264063500059
s:issn
1040-0397
s:numberOfPages
7
n4:doi
10.1002/elan.200804431