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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F09%3A00002127%21RIV10-MZ0-00023001
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Small bowel transplantations (SBT) are increasingly performed to treat patients with irreversible intestinal failure or short-bowel syndrome. Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute cellular rejection (ACR). A reliable serological marker of ACR after SBT is still unknown. Recently, citrulline was identified as a potential biomarker of reduced enterocyte mass. The aim of our study was to analyze rejection and plasma citrulline levels early after SBT in pigs. 24 pigs were used and divided into four groups. Group A, autologous SBT (n = 3) as a control group; Group B, allogeneic SBT with tacrolimus monotherapy (n = 7); Group C, allogeneic SBT immunosuppressed with tacrolimus and sirolimus (n = 8); and Group D, without immunosuppresion (n = 6). The observation period was 30 days. Mucosal biopsies were obtained on Days 0, 3, 5, 7, 10, 14, 20, 28 and simultaneously plasma citrulline levels were measured. ACR was classified according to standardized gra Small bowel transplantations (SBT) are increasingly performed to treat patients with irreversible intestinal failure or short-bowel syndrome. Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute cellular rejection (ACR). A reliable serological marker of ACR after SBT is still unknown. Recently, citrulline was identified as a potential biomarker of reduced enterocyte mass. The aim of our study was to analyze rejection and plasma citrulline levels early after SBT in pigs. 24 pigs were used and divided into four groups. Group A, autologous SBT (n = 3) as a control group; Group B, allogeneic SBT with tacrolimus monotherapy (n = 7); Group C, allogeneic SBT immunosuppressed with tacrolimus and sirolimus (n = 8); and Group D, without immunosuppresion (n = 6). The observation period was 30 days. Mucosal biopsies were obtained on Days 0, 3, 5, 7, 10, 14, 20, 28 and simultaneously plasma citrulline levels were measured. ACR was classified according to standardized gra
dcterms:title
Plasma citrulline levels and acute cellular rejection Plasma citrulline levels and acute cellular rejection
skos:prefLabel
Plasma citrulline levels and acute cellular rejection Plasma citrulline levels and acute cellular rejection
skos:notation
RIV/00023001:_____/09:00002127!RIV10-MZ0-00023001
n5:aktivita
n15:P
n5:aktivity
P(NR8896)
n5:cisloPeriodika
5
n5:dodaniDat
n9:2010
n5:domaciTvurceVysledku
n13:1605569 n13:3749347 n13:4758153 n13:7168187
n5:druhVysledku
n11:J
n5:duvernostUdaju
n8:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
333595
n5:idVysledku
RIV/00023001:_____/09:00002127
n5:jazykVysledku
n16:eng
n5:klicovaSlova
citrulline; small bowel; transplantation
n5:klicoveSlovo
n14:small%20bowel n14:citrulline n14:transplantation
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[93CF898D8CA2]
n5:nazevZdroje
Veterinární medicína
n5:obor
n7:FJ
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
4
n5:projekt
n17:NR8896
n5:rokUplatneniVysledku
n9:2009
n5:svazekPeriodika
54
n5:tvurceVysledku
Baláž, Peter Honsová, Eva Lodererová, Alena Oliverius, Martin
n5:wos
000267269900002
s:issn
0375-8427
s:numberOfPages
8