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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F09%3A00001970%21RIV10-MZ0-00023001
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea
dcterms:title
A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies
skos:prefLabel
A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies
skos:notation
RIV/00023001:_____/09:00001970!RIV10-MZ0-00023001
n4:aktivita
n7:V n7:Z n7:P
n4:aktivity
P(1M0510), V, Z(MZ0IKEM2005)
n4:cisloPeriodika
4
n4:dodaniDat
n12:2010
n4:domaciTvurceVysledku
n9:4176456 n9:6873472 n9:8692548 n9:6513832 n9:7886543
n4:druhVysledku
n10:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
301168
n4:idVysledku
RIV/00023001:_____/09:00001970
n4:jazykVysledku
n13:eng
n4:klicovaSlova
FTO; BMI; polymorphism; menopausal status
n4:klicoveSlovo
n5:BMI n5:polymorphism n5:FTO n5:menopausal%20status
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[94725BEE09B4]
n4:nazevZdroje
Clinical chemistry and laboratory medicine
n4:obor
n16:FB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n17:1M0510
n4:rokUplatneniVysledku
n12:2009
n4:svazekPeriodika
47
n4:tvurceVysledku
Lánská, Věra Hubáček, Jaroslav Adámková, Věra Poledne, Rudolf Piťha, Jan
n4:wos
000266014200002
n4:zamer
n14:MZ0IKEM2005
s:issn
1434-6621
s:numberOfPages
4