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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F09%3A00001968%21RIV10-MZ0-00023001
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated. Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated.
dcterms:title
Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction
skos:prefLabel
Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction
skos:notation
RIV/00023001:_____/09:00001968!RIV10-MZ0-00023001
n3:aktivita
n15:P
n3:aktivity
P(1M0510), P(NR9093)
n3:cisloPeriodika
3
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n5:7886543 n5:6513832 n5:8692548 n5:2335514
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
303710
n3:idVysledku
RIV/00023001:_____/09:00001968
n3:jazykVysledku
n10:eng
n3:klicovaSlova
apolipoprotein E; acute coronary syndrome; polymorphism
n3:klicoveSlovo
n9:acute%20coronary%20syndrome n9:apolipoprotein%20E n9:polymorphism
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[86E5CF2FE181]
n3:nazevZdroje
Folia biologica (Praha)
n3:obor
n14:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n6:1M0510 n6:NR9093
n3:rokUplatneniVysledku
n16:2009
n3:svazekPeriodika
55
n3:tvurceVysledku
Piťha, Jan Hubáček, Jaroslav Skalická, H. Poledne, Rudolf Staněk, Vladimír Aschermann, M.
n3:wos
000267604600006
s:issn
0015-5500
s:numberOfPages
8