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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F08%3A00002768%21RIV12-MZ0-00023001
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://node.nel.edu/?node_id=7258
dcterms:description
BACKGROUND: Pharmakological approach is the most effective way of treatment of ADHD and its early application prevents from the progress of secondary disorders. The study on present neurotransmitter systems in pathology of ADHD can be helpful in selecting appropriate drug, since there are used various substances with different mechanisms of functioning in treatment of the hyperkinetic syndrome. METOD: Within our study there were selected the genes of dopaminergic (DRD2, DRD3, DAT1), noradrenergic (DBH) and serotoninergic (5-HTT) systems. With the use of molecular-genetic methods based on association strategy %22case-control%22 there were analysed genes including 11 polymorphisms. The presence of risk alleles was examined in comparison of the sample of 100 ADHD children to a control group of another 100 subjects, who were checked by child psychiatrists and examined with the Conners test in order to exclude eventual cases with ADHD symptoms. RESULTS: Our research suggests the association of some genes with ADHD. It could be concluded: 1) the risk of ADHD is significantly increased in the presence of one risk allele in genes DRD2 (O.R.= 7,5), 5-HTT (O.R.= 2,7) and DAT 1 (O.R.= 1,6). 2) The risk of ADHD is significantly increased at homozygotes for risk alleles in genes DRD2 (O.R.= 54,8), 5-HTT (O.R.= 6,7) and DAT1 (O.R.= 6,6). For polymorphisms G444A and C1603T in DBH, which were detected by univariant analysis, haplotype analysis was performed and resulted in conclusion that: 3) the risk of ADHD is significantly increased in the presence of allele DBH +444A as well as in the presence of allele DBH +1603T (O.R.= 15). BACKGROUND: Pharmakological approach is the most effective way of treatment of ADHD and its early application prevents from the progress of secondary disorders. The study on present neurotransmitter systems in pathology of ADHD can be helpful in selecting appropriate drug, since there are used various substances with different mechanisms of functioning in treatment of the hyperkinetic syndrome. METOD: Within our study there were selected the genes of dopaminergic (DRD2, DRD3, DAT1), noradrenergic (DBH) and serotoninergic (5-HTT) systems. With the use of molecular-genetic methods based on association strategy %22case-control%22 there were analysed genes including 11 polymorphisms. The presence of risk alleles was examined in comparison of the sample of 100 ADHD children to a control group of another 100 subjects, who were checked by child psychiatrists and examined with the Conners test in order to exclude eventual cases with ADHD symptoms. RESULTS: Our research suggests the association of some genes with ADHD. It could be concluded: 1) the risk of ADHD is significantly increased in the presence of one risk allele in genes DRD2 (O.R.= 7,5), 5-HTT (O.R.= 2,7) and DAT 1 (O.R.= 1,6). 2) The risk of ADHD is significantly increased at homozygotes for risk alleles in genes DRD2 (O.R.= 54,8), 5-HTT (O.R.= 6,7) and DAT1 (O.R.= 6,6). For polymorphisms G444A and C1603T in DBH, which were detected by univariant analysis, haplotype analysis was performed and resulted in conclusion that: 3) the risk of ADHD is significantly increased in the presence of allele DBH +444A as well as in the presence of allele DBH +1603T (O.R.= 15).
dcterms:title
Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age
skos:prefLabel
Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age
skos:notation
RIV/00023001:_____/08:00002768!RIV12-MZ0-00023001
n4:aktivita
n11:P n11:V
n4:aktivity
P(NR9534), V
n4:cisloPeriodika
2
n4:dodaniDat
n5:2012
n4:domaciTvurceVysledku
n15:2959194
n4:druhVysledku
n8:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
395875
n4:idVysledku
RIV/00023001:_____/08:00002768
n4:jazykVysledku
n17:eng
n4:klicovaSlova
ADHD; association study; polymorphisms; DRD2; DRD3; DAT1; DBH; risk alleles; 5-HTT
n4:klicoveSlovo
n9:5-HTT n9:DRD2 n9:ADHD n9:DAT1 n9:DRD3 n9:association%20study n9:risk%20alleles n9:polymorphisms n9:DBH
n4:kodStatuVydavatele
SE - Švédské království
n4:kontrolniKodProRIV
[B47C35BC7498]
n4:nazevZdroje
Neuroendocrinology letters
n4:obor
n12:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n18:NR9534
n4:rokUplatneniVysledku
n5:2008
n4:svazekPeriodika
29
n4:tvurceVysledku
Petrášek, Jan Kopeckova, Marta Malikova, Marcela Paclt, Ivo Zagatova, Veronika Pacltova, Dagmar
n4:wos
000255490000009
s:issn
0172-780X
s:numberOfPages
6