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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F08%3A00002761%21RIV12-MZ0-00023001
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000180269
dcterms:description
Background: Significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). Dysregulation of vascular endothelial growth factor (VEGF) expression in the kidney has been demonstrated in a wide range of renal diseases. The aim of the present study was to assess the influence of the -2578 C/A and the -1154 G/A polymorphisms in the regulatory region of the VEGF gene upon the progression of ADPKD toward end-stage renal disease (ESRD). Methods: The study was performed on 283 ADPKD patients (145 males, 138 females, mean age 51.7 +/- 10.3 years) who had reached ESRD. Patients were divided into three groups: (1) ESRD development later than in 63 years (slow progressors, n = 47), (2) ESRD development before 45 years (rapid progressors, n = 69), and (3) ESRD development between 45 and 63 years (intermediate progressors, n = 167). Genetically unrelated healthy Czech individuals were analyzed as a control group (n = 311, 153 males, 158 females, mean age 44.6 +/- 9.2 years). DNA samples were genotyped for the -2578 C/A and for the - 1154 G/A polymorphisms of the VEGF gene promoter. The serum levels of VEGF were established in 111 healthy Czech individuals from the control group. Results: The VEGF -2578 C/A and -1154 G/A genotype distribution showed no differences among the groups of slow, rapid and intermediate progressors. The age of ESRD with regard to different genotypes was not significantly different in all ADPKD patients. However, the AA genotype of the -2578 C/A polymorphism was associated with a significantly higher age of ESRD than other genotypes in rapid progressors (42.7 vs. 40.5 years, p = 0.01). The CG haplotype was found significantly more frequent in ADPKD rapid progressors than in slow progressors (p = 0.047). Serum levels of VEGF did not significantly differ in the control group, according to different genotypes of both polymorphisms. Conclusion: To conclude, AA genotype of the -2578 C/A polymorphism was related to bette Background: Significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). Dysregulation of vascular endothelial growth factor (VEGF) expression in the kidney has been demonstrated in a wide range of renal diseases. The aim of the present study was to assess the influence of the -2578 C/A and the -1154 G/A polymorphisms in the regulatory region of the VEGF gene upon the progression of ADPKD toward end-stage renal disease (ESRD). Methods: The study was performed on 283 ADPKD patients (145 males, 138 females, mean age 51.7 +/- 10.3 years) who had reached ESRD. Patients were divided into three groups: (1) ESRD development later than in 63 years (slow progressors, n = 47), (2) ESRD development before 45 years (rapid progressors, n = 69), and (3) ESRD development between 45 and 63 years (intermediate progressors, n = 167). Genetically unrelated healthy Czech individuals were analyzed as a control group (n = 311, 153 males, 158 females, mean age 44.6 +/- 9.2 years). DNA samples were genotyped for the -2578 C/A and for the - 1154 G/A polymorphisms of the VEGF gene promoter. The serum levels of VEGF were established in 111 healthy Czech individuals from the control group. Results: The VEGF -2578 C/A and -1154 G/A genotype distribution showed no differences among the groups of slow, rapid and intermediate progressors. The age of ESRD with regard to different genotypes was not significantly different in all ADPKD patients. However, the AA genotype of the -2578 C/A polymorphism was associated with a significantly higher age of ESRD than other genotypes in rapid progressors (42.7 vs. 40.5 years, p = 0.01). The CG haplotype was found significantly more frequent in ADPKD rapid progressors than in slow progressors (p = 0.047). Serum levels of VEGF did not significantly differ in the control group, according to different genotypes of both polymorphisms. Conclusion: To conclude, AA genotype of the -2578 C/A polymorphism was related to bette
dcterms:title
Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease
skos:prefLabel
Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease
skos:notation
RIV/00023001:_____/08:00002761!RIV12-MZ0-00023001
n3:aktivita
n18:Z n18:P
n3:aktivity
P(NR9523), Z(MSM0021620806)
n3:cisloPeriodika
6
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n8:3684342
n3:druhVysledku
n6:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
372350
n3:idVysledku
RIV/00023001:_____/08:00002761
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Vascular endothelial growth factor; Autosomal dominant polycystic kidney disease; Gene promoter polymorphism; Haplotype
n3:klicoveSlovo
n4:Autosomal%20dominant%20polycystic%20kidney%20disease n4:Haplotype n4:Gene%20promoter%20polymorphism n4:Vascular%20endothelial%20growth%20factor
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[7F4A3A45DF24]
n3:nazevZdroje
Kidney and Blood Pressure Research
n3:obor
n11:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n10:NR9523
n3:rokUplatneniVysledku
n16:2008
n3:svazekPeriodika
31
n3:tvurceVysledku
Tesař, Vladimír Vitek, L. Merta, M. Maixnerova, D. Lenicek, M. Stekrova, J. Reiterova, J. Viklický, Ondřej Obeidova, H.
n3:wos
000263506700035
n3:zamer
n20:MSM0021620806
s:issn
1420-4096
s:numberOfPages
6
n12:doi
10.1159/000180269