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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F08%3A00001846%21RIV09-MZ0-00023001
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection. Biologická dostupnost takrolimu a cyklosporinu A je determinována cytochromem P450IIIA a glykoproteinem-P, které jsou kódovány CYP3A4/CYP3A5 a ABCB1 geny. Bylo prokázáno, že tyto geny ovlivňují biologickou dostupnost imunosupresiv a akutní rejekci u pacientů po transplantaci ledviny. Haplotypovou analýzou provedenou na souboru 832 pacientů jsme prokázali, že akutní rejekce byla predikována neshodou v lokusu HLA-DR, opožděným rozvojem funkce štěpu, věkem příjemce v době transplantace a také [ABCB1 +1236C; +2677G; +3435T] haplotypem. Z toho vyplývá, že ABCB1 hyplotypy modifikují riziko akutní rejekce nezávisle na farmakokinetických parametrech. CYP3A haplotypy ovlivňují farmakokinetické parametry takrolimu , ale nemají vztah k riziku akutní rejekce. Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection.
dcterms:title
Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients. Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients. Haplotypová struktura AMCB1/MDR1 genu modifikuje riziko akutní rejekce štěpu u příjemců transplantované ledviny.
skos:prefLabel
Haplotypová struktura AMCB1/MDR1 genu modifikuje riziko akutní rejekce štěpu u příjemců transplantované ledviny. Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients. Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients.
skos:notation
RIV/00023001:_____/08:00001846!RIV09-MZ0-00023001
n3:aktivita
n9:P n9:Z
n3:aktivity
P(NR8816), Z(MZ0IKEM2005)
n3:cisloPeriodika
9
n3:dodaniDat
n7:2009
n3:domaciTvurceVysledku
n4:9859128 n4:3684342 n4:2959194 n4:2876256 n4:9817417 n4:9766782
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
369798
n3:idVysledku
RIV/00023001:_____/08:00001846
n3:jazykVysledku
n17:eng
n3:klicovaSlova
cyclosporine; cytochrome P450; haplotypes; renal transplantation; P-glycoprotein; pharmacogenetics; single nucleotide polymorphism; tacrolimus.
n3:klicoveSlovo
n10:renal%20transplantation n10:P-glycoprotein n10:cytochrome%20P450 n10:single%20nucleotide%20polymorphism n10:haplotypes n10:tacrolimus. n10:pharmacogenetics n10:cyclosporine
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[97C883DD5D4D]
n3:nazevZdroje
Transplantation
n3:obor
n14:FJ
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n13:NR8816
n3:rokUplatneniVysledku
n7:2008
n3:svazekPeriodika
86
n3:tvurceVysledku
Petrášek, Jan Brabcová, Irena Novotná, Eva Hřibová, Petra Bandúr, Štěpán Viklický, Ondřej
n3:wos
000260945600009
n3:zamer
n18:MZ0IKEM2005
s:issn
0041-1337
s:numberOfPages
8