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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F08%3A00001764%21RIV09-MZ0-00023001
rdf:type
n8:Vysledek skos:Concept
dcterms:description
We compared the effect of rosiglitazone (RSG) in adult male rats of two genetically defined models of metabolic syndrome, the PD/Cub and BN.SHR4 rat strains, in contrast to their insulin-sensitive, normolipidemic counterpart, the Brown Norway strain. All rats were fed high-fat diet for the period of four weeks, the experimental groups received RSG (0.4mg/100g body weight) during the last two weeks of HFD-feeding. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with RSG treatment only in PD, corresponding with significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains. The genes with genotype-specific expression change included aquaporin 9, ADAM metallopeptidase domain 7, catechol-O-methyl transferase and carnitine palmitoyltransferase 1B. In conclusion, RSG effects on lipid deposition and insulin sensitivity of peripheral tissues were largely dependent on the diet-modulated, pharmacogenomic i We compared the effect of rosiglitazone (RSG) in adult male rats of two genetically defined models of metabolic syndrome, the PD/Cub and BN.SHR4 rat strains, in contrast to their insulin-sensitive, normolipidemic counterpart, the Brown Norway strain. All rats were fed high-fat diet for the period of four weeks, the experimental groups received RSG (0.4mg/100g body weight) during the last two weeks of HFD-feeding. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with RSG treatment only in PD, corresponding with significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains. The genes with genotype-specific expression change included aquaporin 9, ADAM metallopeptidase domain 7, catechol-O-methyl transferase and carnitine palmitoyltransferase 1B. In conclusion, RSG effects on lipid deposition and insulin sensitivity of peripheral tissues were largely dependent on the diet-modulated, pharmacogenomic i Byl porovnán účinek rosiglitazonu (RSG) u dospělých samců u dvou geneticky definovaných modelů metabolického syndrome, PD/Cub a BN.SHR4 a kontrolního insulin senzitivního kmene Brown Norway. Potkani byli krmeni vysokotukovou dietou po dobu 4 týdnů, experimentální skupina dostávala RSG v dávce 0,4mg/100g tělesné hmotnosti. RGG zvyšoval senzitivitu tukové tkáně k účinku inzulinu u PD potkanů, která byla spojena se vyšší expresí prostaglandin D2 syntázy. RSG pozitivně ovlivnil glukózovou tolerance u všech srovnávaných kmenů. RSG zvýšil expresi genů pro aquaporin 9, ADAM metallopeptidázu, catechol-O-methyl transferázu and carnitine palmitoyltransferázu 1B.Vliv RSG byl závislý na farmakogenomické interakci.
dcterms:title
Pharmacogenomics of metabolic effects of rosiglitazone Pharmacogenomics of metabolic effects of rosiglitazone Faramkogenomika metabolických účinků rosiglitazonu
skos:prefLabel
Pharmacogenomics of metabolic effects of rosiglitazone Pharmacogenomics of metabolic effects of rosiglitazone Faramkogenomika metabolických účinků rosiglitazonu
skos:notation
RIV/00023001:_____/08:00001764!RIV09-MZ0-00023001
n3:aktivita
n4:Z n4:P
n3:aktivity
P(NR8495), Z(MSM0021620807)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2009
n3:domaciTvurceVysledku
n5:3973425 n5:7882092 n5:7556306
n3:druhVysledku
n17:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
386454
n3:idVysledku
RIV/00023001:_____/08:00001764
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Rosiglitazone; metabolic syndrome; lipogenesis; pharmacogenomic interaction
n3:klicoveSlovo
n10:pharmacogenomic%20interaction n10:lipogenesis n10:Rosiglitazone n10:metabolic%20syndrome
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A98EF3123DC1]
n3:nazevZdroje
Pharmacogenomics
n3:obor
n18:FB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:projekt
n12:NR8495
n3:rokUplatneniVysledku
n15:2008
n3:svazekPeriodika
9
n3:tvurceVysledku
Křen, V. Kazdová, Ludmila Hamet, P. Corbeil, G. Křenová, D. Oliyarnyk, Olena Tremblay, J. Šeda, Ondřej Šedová, L.
n3:wos
000257993100002
n3:zamer
n14:MSM0021620807
s:issn
1462-2416
s:numberOfPages
15