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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F07%3A00000817%21RIV08-MZ0-00023001
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Numerous studies have shown that variations in the production and activity of cytokines influence the susceptibility and/or resistance to various infectious agents, autoimmune diseases, and cancer, as well as the predisposition to allograft rejection. Differences in the production of cytokines between individuals are often caused by single nucleotide polymorphisms (SNP) in the promoter or coding regions of cytokine genes. The cytokine polymorphisms of 107 unrelated Caucasian individuals originating from various parts of the Netherlands were studied and compared with the results of two European (Czech and Italian) populations. Twenty-two SNPs of 13 different cytokine genes were analysed. To test the Hardy-Weinberg equilibrium, allele frequencies were estimated by direct gene counting. Evaluation of the allele frequencies of the Dutch, Italian and Czech populations showed that five SNPs were significantly different between the Dutch and the Italians, while these SNPs did not vary between the Dutch and t Vzorek holandské populace byl testován na zastoupení 22 různých polymorfismů genů pro 13 vybraných cytokinů v porovnání s českou a italskou populací. Ukázalo se, že holandská populace se ve frekvenci některých alel liší od italské, nikoliv od české populace. Numerous studies have shown that variations in the production and activity of cytokines influence the susceptibility and/or resistance to various infectious agents, autoimmune diseases, and cancer, as well as the predisposition to allograft rejection. Differences in the production of cytokines between individuals are often caused by single nucleotide polymorphisms (SNP) in the promoter or coding regions of cytokine genes. The cytokine polymorphisms of 107 unrelated Caucasian individuals originating from various parts of the Netherlands were studied and compared with the results of two European (Czech and Italian) populations. Twenty-two SNPs of 13 different cytokine genes were analysed. To test the Hardy-Weinberg equilibrium, allele frequencies were estimated by direct gene counting. Evaluation of the allele frequencies of the Dutch, Italian and Czech populations showed that five SNPs were significantly different between the Dutch and the Italians, while these SNPs did not vary between the Dutch and t
dcterms:title
Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population Genové polymorfismy cytokinů v holandské populaci
skos:prefLabel
Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population Genové polymorfismy cytokinů v holandské populaci
skos:notation
RIV/00023001:_____/07:00000817!RIV08-MZ0-00023001
n3:strany
87-90
n3:aktivita
n4:P n4:N
n3:aktivity
N, P(NR7859), P(NR8276), P(NR8981)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2008
n3:domaciTvurceVysledku
n10:7194641 n10:3456013 n10:8498598
n3:druhVysledku
n17:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
415542
n3:idVysledku
RIV/00023001:_____/07:00000817
n3:jazykVysledku
n15:eng
n3:klicovaSlova
genotypes. HLA
n3:klicoveSlovo
n9:genotypes.%20HLA
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2271D5A91ADF]
n3:nazevZdroje
International journal of immunogenetics
n3:obor
n7:FE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n11:NR7859 n11:NR8276 n11:NR8981
n3:rokUplatneniVysledku
n16:2007
n3:svazekPeriodika
34
n3:tvurceVysledku
Kolesár, Libor Stříž, Ilja Lardy, N. Škorpil, N. Slavčev, Antonij
s:issn
1744-3121
s:numberOfPages
4