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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F06%3A00001337%21RIV08-MZ0-00023001
rdf:type
n7:Vysledek skos:Concept
dcterms:description
This study was performed to examine the role of superoxide formation in the regulation of renal hemodynamic and excretory function and to assess its contribution in the pathogenesis of ANG II-dependent hypertension. Renal responses to acute intra-arterial infusion of the O2(-) scavenger tempol (50 microg x min(-1) x 100 g body wt(-1)) with or without catalase (1,500 U x min(-1) x 100 g(-1); both native and polyethylene glycol-catalase), which reduces H2O2, were evaluated in anesthetized male Sprague-Dawley rats treated chronically with ANG II (65 ng/min) for 2 wk and compared with nontreated control rats. In ANG II-treated hypertensive rats, tempol caused increases in medullary (13 +/- 2%), cortical (5 +/- 2%), and total renal blood flow (9 +/- 2%) without altering systemic arterial pressure. There were also increases in glomerular filtration rate (9 +/- 2%), urine flow (17 +/- 4%), and sodium excretion (26 +/- 5%). However, tempol infusion in nontreated normotensive rats did not cause significant cha This study was performed to examine the role of superoxide formation in the regulation of renal hemodynamic and excretory function and to assess its contribution in the pathogenesis of ANG II-dependent hypertension. Renal responses to acute intra-arterial infusion of the O2(-) scavenger tempol (50 microg x min(-1) x 100 g body wt(-1)) with or without catalase (1,500 U x min(-1) x 100 g(-1); both native and polyethylene glycol-catalase), which reduces H2O2, were evaluated in anesthetized male Sprague-Dawley rats treated chronically with ANG II (65 ng/min) for 2 wk and compared with nontreated control rats. In ANG II-treated hypertensive rats, tempol caused increases in medullary (13 +/- 2%), cortical (5 +/- 2%), and total renal blood flow (9 +/- 2%) without altering systemic arterial pressure. There were also increases in glomerular filtration rate (9 +/- 2%), urine flow (17 +/- 4%), and sodium excretion (26 +/- 5%). However, tempol infusion in nontreated normotensive rats did not cause significant cha tvorba superoxidu, patogeneze ANG II-dependentní hypertenze
dcterms:title
Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats Intenzivnější tvorba superoxidů ovlivňuje u krys s hypertenzí indukovanou ANG-II funkci ledvin
skos:prefLabel
Intenzivnější tvorba superoxidů ovlivňuje u krys s hypertenzí indukovanou ANG-II funkci ledvin Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats
skos:notation
RIV/00023001:_____/06:00001337!RIV08-MZ0-00023001
n3:strany
F80-F86
n3:aktivita
n4:N
n3:aktivity
N
n3:cisloPeriodika
1
n3:dodaniDat
n10:2008
n3:domaciTvurceVysledku
n12:4763610
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
474227
n3:idVysledku
RIV/00023001:_____/06:00001337
n3:jazykVysledku
n13:eng
n3:klicovaSlova
superoxide; angiotensin II
n3:klicoveSlovo
n6:angiotensin%20II n6:superoxide
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[633519D7E1A8]
n3:nazevZdroje
American Journal of Physiology-Renal Physiology
n3:obor
n5:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n10:2006
n3:svazekPeriodika
290
n3:tvurceVysledku
Kopkan, Libor Navar, G. Majid, D. S. A. Castillo, L.
s:issn
0363-6127
s:numberOfPages
7