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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F06%3A00000666%21RIV07-MSM-00023001
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Consistent results have been published about the A-204C promoter variant in cholesterol 7 α hydroxylase (CYP7A1) gene. CYP7A1 is a rate-limiting enzyme in the bile acid synthesis and plays an important role in keeping the cholesterol homeostasis. CYP7A1 CC homozygotes have the highest decrease of total cholesterol in response to the dietary changes in different types of dietary intervention studies. In contrast one study described that LDL-cholesterol lowering effect of statins was slightly higher in A-204A homozygotes. O A-204C variantě v promoteru genu pro cholesterol 7 α hydroxylázu (CYP7A1) byly publikovány konzistentní výsledky. CYP7A1 je klíčovým enzymem syntézy žlučových kyselin a hraje důležitou roli v udržování rovnováhy cholesterolu v organismu. CYP7A1 CC homozygoti mají nejlepší odpověď na dietně indukovanou změnu cholesterolu. Nicméně, naopak, cholesterol snižující efekt statinů je poněkud výraznější u A-204A homozygotů. Consistent results have been published about the A-204C promoter variant in cholesterol 7 α hydroxylase (CYP7A1) gene. CYP7A1 is a rate-limiting enzyme in the bile acid synthesis and plays an important role in keeping the cholesterol homeostasis. CYP7A1 CC homozygotes have the highest decrease of total cholesterol in response to the dietary changes in different types of dietary intervention studies. In contrast one study described that LDL-cholesterol lowering effect of statins was slightly higher in A-204A homozygotes.
dcterms:title
Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Cholesterol 7alfa-hydroxyláza (CYP7A1) a její role v nutrigenetice a farmakogenetice snižování cholesterolu
skos:prefLabel
Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Cholesterol 7alfa-hydroxyláza (CYP7A1) a její role v nutrigenetice a farmakogenetice snižování cholesterolu
skos:notation
RIV/00023001:_____/06:00000666!RIV07-MSM-00023001
n3:strany
93-100
n3:aktivita
n10:P
n3:aktivity
P(1M0510)
n3:cisloPeriodika
2
n3:dodaniDat
n6:2007
n3:domaciTvurceVysledku
n11:3730883 n11:6513832
n3:druhVysledku
n5:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
497865
n3:idVysledku
RIV/00023001:_____/06:00000666
n3:jazykVysledku
n7:eng
n3:klicovaSlova
metabolism; genetics; nutrition
n3:klicoveSlovo
n9:genetics n9:metabolism n9:nutrition
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[22DBE52875D7]
n3:nazevZdroje
Molecular diagnosis and therapy
n3:obor
n4:FA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n13:1M0510
n3:rokUplatneniVysledku
n6:2006
n3:svazekPeriodika
10
n3:tvurceVysledku
Bobková, Dagmar Hubáček, Jaroslav
s:issn
1177-1062
s:numberOfPages
8