This HTML5 document contains 35 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n15http://linked.opendata.cz/ontology/domain/vavai/cep/typPojektu/
n17http://linked.opendata.cz/ontology/domain/vavai/cep/druhSouteze/
n13http://linked.opendata.cz/ontology/domain/vavai/cep/zivotniCyklusProjektu/
n10http://linked.opendata.cz/ontology/domain/vavai/cep/hodnoceniProjektu/
dctermshttp://purl.org/dc/terms/
n5http://linked.opendata.cz/resource/domain/vavai/projekt/MEB040703/
n2http://linked.opendata.cz/resource/domain/vavai/projekt/
n19http://linked.opendata.cz/resource/domain/vavai/subjekt/
n16http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/
n8http://linked.opendata.cz/ontology/domain/vavai/
n6http://linked.opendata.cz/ontology/domain/vavai/cep/kategorie/
n7http://linked.opendata.cz/ontology/domain/vavai/cep/duvernostUdaju/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n21http://linked.opendata.cz/ontology/domain/vavai/cep/fazeProjektu/
n12http://linked.opendata.cz/ontology/domain/vavai/cep/obor/
n9http://linked.opendata.cz/ontology/domain/vavai/cep/statusZobrazovaneFaze/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
xsdhhttp://www.w3.org/2001/XMLSchema#
n4http://linked.opendata.cz/ontology/domain/vavai/cep/
n20http://linked.opendata.cz/resource/domain/vavai/aktivita/
n11http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:MEB040703
rdf:type
n8:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=MEB040703
dcterms:description
A number of studies, including our own preliminary data, have shown that TRAIL (an important member of the TNF family) works synergistically with some anticancer drugs to kill most types of tumor cells and reversed resistance to such drugs. These findings indicate that the combination of TRAIL and chemotherapeutic drugs is potentially promising in treating refractory cancers. TRAIL can induce human cancer cell apoptosis through engagement of its death receptors DR4 and DR5. However, not all cancers are sensitive to this cytokine. Recently, it was shown that low doses of cytotoxic drugs could restore TRAIL-induced cell death in resistant colon and prostate cancer cell lines. Taken together, finding mechanisms leading to sensitizing the cancer cells to chemotherapy represent a useful approach for identifying new and/or improving existing anti-cancer strategies. The general aims of the proposal are 1) To identify if and how the treatment of the cells by DHA modulate association of selected death recep A number of studies, including our own preliminary data, have shown that TRAIL (an important member of the TNF family) works synergistically with some anticancer drugs to kill most types of tumor cells and reversed resistance to such drugs. These findings indicate that the combination of TRAIL and chemotherapeutic drugs is potentially promising in treating refractory cancers. TRAIL can induce human cancer cell apoptosis through engagement of its death receptors DR4 and DR5. However, not all cancers are sensitive to this cytokine. Recently, it was shown that low doses of cytotoxic drugs could restore TRAIL-induced cell death in resistant colon and prostate cancer cell lines. Taken together, finding mechanisms leading to sensitizing the cancer cells to chemotherapy represent a useful approach for identifying new and/or improving existing anti-cancer strategies. The general aims of the proposal are 1) To identify if and how the treatment of the cells by DHA modulate association of selected death recep
dcterms:title
Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells Úloha lipidových raftů v řízení buněčné signalizace vedoucí k modulaci cytokinetiky nádorových buněk
skos:notation
MEB040703
n4:aktivita
n20:ME
n4:celkovaStatniPodpora
n5:celkovaStatniPodpora
n4:celkoveNaklady
n5:celkoveNaklady
n4:datumDodatniDoRIV
2010-05-07+02:00
n4:druhSouteze
n17:M2
n4:duvernostUdaju
n7:S
n4:fazeProjektu
n21:69261424
n4:hlavniObor
n12:ED
n4:hodnoceniProjektu
n10:U
n4:kategorie
n6:ZV
n4:klicovaSlova
cancer- cell signalling- lipid rafts- TRAIL- cisplatin- colocalization- FRET- cytometry-
n4:partnetrHlavni
n19:ico%3A68081707
n4:pocetKoordinujicichPrijemcu
0
n4:pocetPrijemcu
1
n4:pocetSpoluPrijemcu
0
n4:pocetVysledkuRIV
0
n4:pocetZverejnenychVysledkuVRIV
0
n4:posledniUvolneniVMinulemRoce
2008-08-13+02:00
n4:prideleniPodpory
n16:6078%2F2008-32
n4:sberDatUcastniciPoslednihoRoku
n11:2008
n4:sberDatUdajeProjZameru
n11:2009
n4:statusZobrazovaneFaze
n9:DUU
n4:typPojektu
n15:P
n4:ukonceniReseni
2008-12-31+01:00
n4:zahajeniReseni
2008-01-01+01:00
n4:zhodnoceni+vysledku+projektu+dodavatelem
The main contribution was on the methodological level. The results demonstrated that Pt-cytostatics may modulate signalling of TRAIL by different mechanisms - changes of cell membrane, expression of receptors and kinetics of internalization of TRAIL. Hlavní přínos byl v oblasti metodologické. Dále výsledky ukázaly, že Pt-cytostatika mohou modulovat signální dráhu TRAIL pomocí řady různých mechanismů, které zahrnují změny na úrovni buněčné membrány, exprese receptorů i kinetiky internalizace TRAIL.
n4:zivotniCyklusProjektu
n13:JU