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Namespace Prefixes

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Statements

Subject Item
n2:GP310%2F01%2FP030
rdf:type
n13:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=GP310/01/P030
dcterms:description
A number of exogenous chemical compounds (xenobiotics) continuously affects the human organism, some of them cause the damage of DNA, or proteins. Polycyclic aromatic hydrocarbons (PAHs) are important pollutants, that are adsorbed to respirable air particles (<2.5 u.m) resulted from processes of incomplete combustion. These xenobiotics can be received even by the food chain. Some of PAHs have been identified as possible carcinogens to humans. Biomarkers are defined as indicators of exposure and effect of xenobiotics on human organism. Heat shock proteins have been found to be very sensitive biomarkers of environmental pollution, hsp32 protein is important for the degradation of heme to bilirubin; its expression is induced for example by cytochrome P450. This cytochrome is induced after the exposure to PAHs. hsp70 proteins help to repair denatured, or abnormal proteins, they also stabilize proteins. The purposes of the project: to investigate, if hsp32 and hsp70 proteins are expressed as Lidskě organismus je kontinu lnŘ vystavov n p…sobeni cel‚ ýady exogennˇch chemickěch l tek (xenobiotik), z nich§ mnoh‚ poçkozujˇ DNA nebo proteiny. Mezi věznamn‚ çkodliviny patýˇ i polycyklick‚ aromatick‚ uhlovodˇky (PAU), kter‚ jsou v ovzduçˇ adsorbov nna respirabilnˇ ź stice (<2,5 mě m), jejich§ zdrojem jsou r…zn‚ procesy nedokonal‚ho spalov nˇ. Tyto cizorod‚ l tky mohou bět pýijˇm ny i potravinověm ýetŘzcem. Mnoh‚ PAU se ýadˇ mezi potenci lnˇ karcinogeny pro źlovŘka. Biomarkery jsou indik tory, kter‚umo§ĺujˇ sledovat vliv xenobiotik na §ivě organismus. Proteiny teplotnˇho çoku (hsp) mohou bět citlivěmi biomarkery zneźiçtŘn‚ho prostýedˇ. Protein hsp32 se podˇlˇ na pýemŘnŘ hemu na bilirubin; jeho exprese je indukov na napr. cytochromem P450. Tento cytochrom je indukov n po p…sobenˇ PAU. Proteiny skupiny hsp70 se uplatĺujˇ pýi opravŘ denaturovaněch nebo jinak poçkozeněch protein… a mohou se tak‚ podˇlet na jejich stabilizaci. Cˇle navrhovan‚ho projektu: a) prok zat expresi protein… hsp32 a hsp70
dcterms:title
Heat shock proteins as biomarkers of exposure to polycyclic aromatic hydrocarbons Proteiny teplotnˇho çoku jako biomarkery expozice polycyklickěm aromatickěm uhlovodˇk…m
skos:notation
GP310/01/P030
n3:aktivita
n4:GP
n3:celkovaStatniPodpora
n7:celkovaStatniPodpora
n3:celkoveNaklady
n7:celkoveNaklady
n3:datumDodatniDoRIV
2009-06-15+02:00
n3:druhSouteze
n12:VS
n3:duvernostUdaju
n15:S
n3:fazeProjektu
n17:1163414
n3:hlavniObor
n8:EB
n3:hodnoceniProjektu
n5:U
n3:klicovaSlova
Neuvedeno.
n3:partnetrHlavni
n18:ico%3A68378041
n3:pocetKoordinujicichPrijemcu
0
n3:pocetPrijemcu
1
n3:pocetSpoluPrijemcu
0
n3:pocetVysledkuRIV
2
n3:pocetZverejnenychVysledkuVRIV
2
n3:sberDatUcastniciPoslednihoRoku
n16:2003
n3:sberDatUdajeProjZameru
n16:2003
n3:soutez
n11:SGA02002GA-PD
n3:statusZobrazovaneFaze
n10:DUS
n3:typPojektu
n19:P
n3:vedlejsiObor
n8:FN
n3:zhodnoceni+vysledku+projektu+dodavatelem
Projekt byl pýedźasnŘ ukonźen na § dost ýeçitele, vzhledem k dlouhodob‚ zahraniźnˇ st §i. V r mci projektu byla sledov na exprese dvou protein… tepeln‚ho çoku a to Hsp32 a Hsp 70. Pýedpokl dalo se, §e exprese tŘchto molekul m…§e bět vyu§ita jako biomolek
n3:zivotniCyklusProjektu
n20:ZBS