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Statements

Subject Item
n2:GP204%2F09%2FP563
rdf:type
n18:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=GP204/09/P563
dcterms:description
F0F1-ATP synthase plays an essential role in Trypanosoma brucei, an important pathogen of humans and livestock that alternates between an insect vector and a mammalian host. Interestingly, the function of the mitochondrial (mt) F0F1-ATP synthase differs between the insect and mammalian stages, producing ATP in the former while consuming ATP to maintain the mt membrane potential in the latter. Purification of this complex revealed 18 subunits, of which 12 do not possess any obvious homology to any other proteins. The proposed aim of this project is to resolve the function of two of these novel subunits within the F0F1-ATP synthase. We will determine if these two proteins are involved in the structural organization of the complex, in its oligomerization and/or in regulation of the different enzymatic activities found during the two life cycle stages. We will also elucidate the specific interaction partners of these two proteins within the F0 or F1 moieties. The obtained results will expand our knowledge about this intriguing complex and may open new opportunities for drug development. Cílem tohoto projektu je objasnit funkci dvou nových podjednotek komplexu F0F1-ATP syntázy v hmyzím a savčím stádiu trypanozóm. Zjistíme, zda tyto proteiny jsou životně důležité pro tohoto prvoka, zda mají strukturní roli, či jsou nezbytné pro regulaci enzymatických aktivitit tohoto komplexu.
dcterms:title
Functional analysis of two novel subunits of the F0F1-ATP synthase complex in Trypanosoma brucei Funkční analýza dvou nových podjednotek komplexu F0F1-ATP syntázy u Trypanosoma brucei
skos:notation
GP204/09/P563
n4:aktivita
n14:GP
n4:celkovaStatniPodpora
n13:celkovaStatniPodpora
n4:celkoveNaklady
n13:celkoveNaklady
n4:datumDodatniDoRIV
2015-03-02+01:00
n4:druhSouteze
n17:VS
n4:duvernostUdaju
n21:S
n4:fazeProjektu
n20:91733353
n4:hlavniObor
n6:EB
n4:hodnoceniProjektu
n22:U
n4:kategorie
n19:ZV
n4:klicovaSlova
Trypanosoma; mitochondrie; ATP syntáza; RNA interference
n4:partnetrHlavni
n5:ico%3A60077344
n4:pocetKoordinujicichPrijemcu
0
n4:pocetPrijemcu
1
n4:pocetSpoluPrijemcu
0
n4:pocetVysledkuRIV
1
n4:pocetZverejnenychVysledkuVRIV
1
n4:posledniUvolneniVMinulemRoce
2011-04-16+02:00
n4:prideleniPodpory
n11:204%2F09%2FP563
n4:sberDatUcastniciPoslednihoRoku
n12:2011
n4:sberDatUdajeProjZameru
n12:2012
n4:soutez
n8:SGA02009GA1PD
n4:statusZobrazovaneFaze
n7:DUU
n4:typPojektu
n16:P
n4:ukonceniReseni
2011-12-31+01:00
n4:vedlejsiObor
n6:CE
n4:zahajeniReseni
2009-01-01+01:00
n4:zhodnoceni+vysledku+projektu+dodavatelem
The project gone according to plan both in terms of expertise and in terms of disbursement of funds. Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků.
n4:zivotniCyklusProjektu
n10:ZBKU
n4:klicoveSlovo
mitochondrie ATP syntáza Trypanosoma