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Statements

Subject Item
n2:GA309%2F09%2F1696
rdf:type
n21:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=GA309/09/1696
dcterms:description
V předkládaném projektu budeme studovat, zda poškození astrocytů může být počátečním jevem v patogenezi Alzheimerovy choroby a zda může přispívat k úbytku synapsí a následnému vzniku neuronální patologie. Understanding the early cellular events in the development of Alzheimer's disease (AD) is pivotal for the development of novel diagnostic tools and disease modifying therapies. While neuronal pathology has been studied extensively the involvement of glia in the development of the primary pathology has been largely ignored. In Alzheimer's disease most of the glial changes are regarded as secondary to neuronal or synaptic loss. However, glial cells, especially astrocytes have an active role in the formation and stability of synaptic connections, maintain extracellular brain homeostasis (controlling neurotransmitters and ion concentrations), provide neurones with energy (through the glucose-lactate shuttle), establish functional link with brain microcirculation and create the microdomain organisation of grey matter represented in a form of neuronal-glial-vascular units. Any failure in astroglial function therefore results in instant impairments of brain connectivity, synaptic strength and overall performance of neural circuits. Here we will test our hypothesis that the disruption of astrocytes might be an early event in the pathogenesis of AD, which contributes to the synaptic loss and subsequently the formation of the well known neuronal pathology.
dcterms:title
Patologický potenciál astroglie v průběhu Alzheimerovy choroby Pathological potential of astroglia in Alzheimer disease
skos:notation
GA309/09/1696
n3:aktivita
n10:GA
n3:celkovaStatniPodpora
n12:celkovaStatniPodpora
n3:celkoveNaklady
n12:celkoveNaklady
n3:datumDodatniDoRIV
2015-03-02+01:00
n3:druhSouteze
n14:VS
n3:duvernostUdaju
n6:S
n3:fazeProjektu
n18:91497639
n3:hlavniObor
n20:FH
n3:hodnoceniProjektu
n11:V
n3:kategorie
n4:ZV
n3:klicovaSlova
gliové buňky; patogeneze; neurodegenerace
n3:partnetrHlavni
n5:ico%3A68378041
n3:pocetKoordinujicichPrijemcu
0
n3:pocetPrijemcu
1
n3:pocetSpoluPrijemcu
0
n3:pocetVysledkuRIV
23
n3:pocetZverejnenychVysledkuVRIV
23
n3:posledniUvolneniVMinulemRoce
2011-04-16+02:00
n3:prideleniPodpory
n8:309%2F09%2F1696
n3:sberDatUcastniciPoslednihoRoku
n15:2011
n3:sberDatUdajeProjZameru
n15:2012
n3:soutez
n16:SGA02009GA-ST
n3:statusZobrazovaneFaze
n7:DUU
n3:typPojektu
n17:P
n3:ukonceniReseni
2011-12-31+01:00
n3:zahajeniReseni
2009-01-01+01:00
n3:zhodnoceni+vysledku+projektu+dodavatelem
The project was excellent, both in terms of expertise and in terms of disbursement of funds. Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků.
n3:zivotniCyklusProjektu
n19:ZBKU
n3:klicoveSlovo
patogeneze gliové buňky