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Statements

Subject Item
n2:7E13005
rdf:type
n20:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=7E13005 http://www.denamic-project.eu
dcterms:description
Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methodsfor early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder. Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methodsfor early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.
dcterms:title
Developmental neurotoxicity assessment of mixtures in children Developmental neurotoxicity assessment of mixtures in children
skos:notation
7E13005
n3:aktivita
n8:7E
n3:celkovaStatniPodpora
n13:celkovaStatniPodpora
n3:celkoveNaklady
n13:celkoveNaklady
n3:datumDodatniDoRIV
2015-04-02+02:00
n3:druhSouteze
n12:RP
n3:duvernostUdaju
n6:S
n3:fazeProjektu
n4:101089094
n3:hlavniObor
n21:DN
n3:kategorie
n5:ZV
n3:klicovaSlova
Neurotoxicity; Environmental pollutants; Children; Health
n3:partnetrHlavni
n15:orjk%3A14310
n3:pocetKoordinujicichPrijemcu
0
n3:pocetPrijemcu
1
n3:pocetSpoluPrijemcu
0
n3:pocetVysledkuRIV
0
n3:pocetZverejnenychVysledkuVRIV
0
n3:posledniUvolneniVMinulemRoce
2014-03-20+01:00
n3:prideleniPodpory
n10:MSMT-42111%2F2013
n3:sberDatUcastniciPoslednihoRoku
n18:2015
n3:sberDatUdajeProjZameru
n18:2015
n3:statusZobrazovaneFaze
n19:DRRVK
n3:typPojektu
n7:P
n3:ukonceniReseni
2015-12-31+01:00
n3:zahajeniReseni
2013-01-01+01:00
n3:zivotniCyklusProjektu
n9:ZBK
n3:vyzva
n14:FP7-ENV-2011
n3:klicoveSlovo
Neurotoxicity Children Environmental pollutants