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Statements

Subject Item
n2:7E11016
rdf:type
n11:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=7E11016
dcterms:description
Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determinants but also the neuromuscular condition. The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any prediction based on external and indirect determinants, as it is current clinical practice. These predictions will be used to: i) improve the diagnostic accuracy of the current clinical standards; ii) to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton. For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure. The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations. Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determinants but also the neuromuscular condition. The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any prediction based on external and indirect determinants, as it is current clinical practice. These predictions will be used to: i) improve the diagnostic accuracy of the current clinical standards; ii) to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton. For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure. The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations.
dcterms:title
Osteoporotic Virtual Physiological Human Osteoporotic Virtual Physiological Human
skos:notation
7E11016
n3:aktivita
n13:7E
n3:celkovaStatniPodpora
n7:celkovaStatniPodpora
n3:celkoveNaklady
n7:celkoveNaklady
n3:datumDodatniDoRIV
2013-06-28+02:00
n3:druhSouteze
n15:RP
n3:duvernostUdaju
n4:S
n3:fazeProjektu
n5:92903304
n3:hlavniObor
n18:JC
n3:hodnoceniProjektu
n21:U
n3:kategorie
n17:AP
n3:klicovaSlova
bone fracture; multiscale modelling; osteoporosis; physiome; VPH
n3:partnetrHlavni
n6:orjk%3A23520
n3:pocetKoordinujicichPrijemcu
0
n3:pocetPrijemcu
1
n3:pocetSpoluPrijemcu
0
n3:pocetVysledkuRIV
2
n3:pocetZverejnenychVysledkuVRIV
2
n3:posledniUvolneniVMinulemRoce
2012-04-04+02:00
n3:prideleniPodpory
n12:13595%2F2011+%E2%80%93+321
n3:sberDatUcastniciPoslednihoRoku
n22:2012
n3:sberDatUdajeProjZameru
n22:2013
n3:statusZobrazovaneFaze
n20:DUU
n3:typPojektu
n8:P
n3:ukonceniReseni
2012-10-31+01:00
n3:zahajeniReseni
2011-01-01+01:00
n3:zhodnoceni+vysledku+projektu+dodavatelem
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider. Hodnocení výsledků řešení ministerstvo neprovádí, neboť podmínkou podpory je, že uchazeč byl vybrán mezinárodním poskytovatelem v souladu s pravidly příslušného programu. Projekt je hodnocen až po jeho schválení mezinárodním poskytovatelem.
n3:zivotniCyklusProjektu
n16:ZKU
n3:vyzva
n19:FP7-ICT-2007-2
n3:klicoveSlovo
multiscale modelling bone fracture osteoporosis physiome