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Statements

Subject Item

n2:7E11026

rdf:type

n3:Projekt

dcterms:description

Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells. Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells.

dcterms:title

Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells

n3:cislo-smlouvy

n5:2011 \u2013 321

n3:dalsi-vedlejsi-obor

n10:CF

n3:druh-souteze

n11:RP

n3:faze

n13:54616537

n3:hlavni-obor

n10:FD

n3:vedlejsi-obor

n10:EC

n3:id-aktivity

n12:7E

n3:id-souteze

n4:

n3:kategorie

n7:1

n3:klicova-slova

nanodiamonds, cell biology, gene probe/reader, gene therapeutics, cancer stem cells, saccharide vector, antibody protein vector, gene-targeting, miRNA, biological imaging

n3:konec-reseni

2013-04-30+01:00

n3:pocet-koordinujicich-prijemcu

0

n3:poskytovatel

n6:MSM

n3:start-reseni

2011-01-01+01:00

n3:statni-podpora

3081

n3:typProjektu

n9:P

n3:uznane-naklady

3081

n3:pocet-prijemcu

1

n3:pocet-spoluprijemcu

0

n3:pocet-vysledku

0

n3:pocet-vysledku-zverejnovanych

0