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Statements

Subject Item
n2:P457
rdf:type
n4:Projekt
dcterms:description
Immunophenotypisation of plasma cells using multiparametric flow cytometry brings enough data to define and distinguish heterogeneous population of neoplastic plasma cells from their normal equivalent. The aim of this project is to identify phenotypic profile in subjects with monoclonal gammopathy. The pathophysiology of plasma cells and changes in their behavior will be studied on cellular and molecular level to detect possible relationship between these changes and possibility of malignant transformation in monoclonal gammopathy of undetermined significance. This project can be used to identify new predictive and prognostic markers. They could lead to definite determination of diagnose, assessment of risk of progression in asymptomatic monoclonal gammopathies with consequent well-timed and accurately targeted treatment. The markers also could help to evaluate minimal residual disease and efficacy of treatment. Srovnání fenotypového profilu normálních a patologických plazmocytů pomocí multi/polychromatické průtokové cytometrie. Charakterizace a selekce plazmocytů za účelem jejich dalších analýz. Predikce rizika progrese/relapsu. Přínos flowcytometrie pro hodnocení minimální reziduální choroby.
dcterms:title
Multiparametric flow cytometry in study of malignant plasma cells pathophysiology Uplatnění multiparametrické průtokové cytometrie ve studiu patofyziologie maligních plazmatických buněk
n4:cislo-smlouvy
n12:P457
n4:dalsi-vedlejsi-obor
n5:EB
n4:druh-souteze
n9:VS
n4:faze
n7:52807938
n4:hlavni-obor
n5:FD
n4:vedlejsi-obor
n5:EC
n4:id-aktivity
n6:GP
n4:id-souteze
n11:SGA02009GA1PD
n4:kategorie
n13:1
n4:klicova-slova
monoklonální gamapatie; mnohočetný myelom; plazmatické buňky; průtoková cytometrie
n4:konec-reseni
2011-12-31+01:00
n4:pocet-koordinujicich-prijemcu
0
n4:poskytovatel
n8:GA0
n4:start-reseni
2009-03-01+01:00
n4:statni-podpora
1200
n4:typProjektu
n10:P
n4:uznane-naklady
1200
n4:pocet-prijemcu
1
n4:pocet-spoluprijemcu
0
n4:pocet-vysledku
12
n4:pocet-vysledku-zverejnovanych
12