About: iodine I 131 NM404     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • iodine I 131 NM404
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • iodine I 131 NM404
NCI_META_CUI
  • CL433302
PDQ_Open_Trial_Search_ID
  • 722308
PDQ_Closed_Trial_Search_ID
  • 722308
FULL_SYN
  • [(131)I]NM404SYNCI
  • iodine I 131 NM404PTNCI
  • 131I-NM404SYNCI
DEFINITION
  • A phospholipid ether analog labeled with iodine I 131, with potential radiotherapeutic and radioimaging potential upon positron emission tomography (PET). Upon administration, iodine I 131 NM404 selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD), most likely isoform 1 of PLD, in tumor cells compared to normal cells. As tumor cells are unable to metabolize and eliminate MN404, tumor cells can be visualized upon PET imaging. In addition, iodine I 131 NM404 selectively delivers a cytotoxic dose of iodine I 131 to the tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.NCI
code
  • C99637
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