About: Iodine I 124 NM404     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Iodine I 124 NM404
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Iodine I 124 NM404
NCI_META_CUI
  • CL433301
PDQ_Open_Trial_Search_ID
  • 722307
PDQ_Closed_Trial_Search_ID
  • 722307
FULL_SYN
  • [(124)I]NM404SYNCI
  • Iodine I 124 NM404PTNCI
  • 124I-NM404SYNCI
DEFINITION
  • A phospholipid ether analog labeled with iodine I 124, with a potential imaging property upon positron emission tomography (PET). Upon administration, iodine I 124 NM404 selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD), most likely isoform 1 of PLD, in tumor cells compared to normal cells. As tumor cells are unable to metabolize and eliminate MN404, tumor cells can be visualized upon PET imaging. In addition, iodine I 124 NM404 may provide a more accurate image of the tumor than imaging with the current standard. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.NCI
code
  • C99636
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