About: Imidapril Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Imidapril Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Imidapril Hydrochloride
UMLS_CUI
  • C0872994
CAS_Registry
  • 89396-94-1
FDA_UNII_Code
  • 7NSF9GG1NU
Contributing_Source
  • FDA
Chemical_Formula
  • C20H27N3O6.ClH
FULL_SYN
  • Imidapril HydrochloridePTNCI
  • IMIDAPRIL HYDROCHLORIDEPTFDA7NSF9GG1NU
  • (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic Acid, HydrochlorideSNNCI
DEFINITION
  • The hydrochloride salt of imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C99550
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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