About: RUNX1/ZFPM2 Fusion Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • RUNX1/ZFPM2 Fusion Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • RUNX1/ZFPM2 Fusion Gene
PubMedID_Primary_Reference
  • 15705784
UMLS_CUI
  • C1863595
FULL_SYN
  • RUNX1-ZFPM2 Fusion GeneSYNCI
  • RUNX1/ZFPM2 Fusion GenePTNCI
  • AML1-FOG2 Fusion GeneSYNCI
  • AML1/FOG2 Fusion GeneSYNCI
DEFINITION
  • A fusion gene that results from a cryptic chromosomal rearrangement which fuses the first 6 exons of the RUNX1 gene to exon 6 of the ZFPM2 gene. This rearrangement is associated with one case of refractory anemia with excess blasts.NCI
DesignNote
  • Chan et al. (2005) described a t(X;21)(p22.3;q22.1) translocation in a patient with myelodysplasia that fused the RUNX1 gene with the ZFPM2 gene. They anticipated that the partner gene would be located on the X chromosome, but using FISH, they showed that the ZFPM2 gene had been translocated from chromosome 8 to the X chromosome, indicating that a complex chromosomal rearrangement had occurred in this patient.
code
  • C99298
is someValuesFrom of
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