About: Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells
NCI_META_CUI
  • CL433046
PDQ_Open_Trial_Search_ID
  • 717909
PDQ_Closed_Trial_Search_ID
  • 717909
FULL_SYN
  • Allogeneic CD19CAR-TCM CellsSYNCI
  • Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T CellsPTNCI
DEFINITION
  • A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells exert antiviral immunity.NCI
code
  • C99215
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