About: PML/RARA Fusion Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PML/RARA Fusion Gene
rdfs:subClassOf
GenBank_Accession_Number
  • M73779
Semantic_Type
  • Gene or Genome
Preferred_Name
  • PML/RARA Fusion Gene
UMLS_CUI
  • C1867259
FULL_SYN
  • PML-RAR Alpha Fusion GeneSYNCI
  • PML/RARA Fusion GeneSYNCITCGA
  • PML-RARSYNCI
  • PML-RARA Fusion GeneSYNCI
  • PML/RARA Fusion GenePTNCI
DEFINITION
  • A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 3 exons of the PML gene with the last 7 exons of the RARA gene. This fusion is associated with acute promyelocytic leukemia. Three transcript variants are possible based on the three breakpoint clusters in the PML gene.NCI
DesignNote
  • The translocation, well known as t(15;17)(q22;q21) or t(15;17)(q22;q12), should be re-named t(15;17)(q24;q21), since the PML gene is located in the vicinity of 15q24, and the RARA gene is located in the vicinity of 17q21. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)
code
  • C99186
is someValuesFrom of
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