About: Yttrium Y 90 Basiliximab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Yttrium Y 90 Basiliximab
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Yttrium Y 90 Basiliximab
NCI_META_CUI
  • CL433016
PDQ_Open_Trial_Search_ID
  • 717514
PDQ_Closed_Trial_Search_ID
  • 717514
FULL_SYN
  • Yttrium Y 90 BasiliximabPTNCI
  • 90Y BasiliximabSYNCI
DEFINITION
  • A radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal antibody directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha, CD25 or Tac antigen), and labeled with yttrium y 90, with potential antineoplastic activity. The basiliximab moiety of yttrium Y 90 basiliximab selectively binds to IL-2R alpha expressed on the surface of activated T-lymphocytes, thereby preventing IL-2 binding and blocking the IL-2-mediated activation of lymphocytes. The yttrium y 90 moiety selectively delivers a cytotoxic dose of beta radiation to lymphocytes that express the IL-2 receptor. This may prevent T cell-mediated activation of the immune system against a certain transplant and may prevent transplant rejection.NCI
code
  • C99167
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