About: p38 MAPK Inhibitor LY3007113     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • p38 MAPK Inhibitor LY3007113
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • p38 MAPK Inhibitor LY3007113
NCI_META_CUI
  • CL432952
PDQ_Open_Trial_Search_ID
  • 716106
PDQ_Closed_Trial_Search_ID
  • 716106
FULL_SYN
  • p38 MAPK Inhibitor LY3007113PTNCI
  • LY3007113CNNCI
DEFINITION
  • An orally active p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activity. Upon administration, LY3007113 inhibits the activity of p38, thereby preventing p38 MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines and the induction of tumor cell apoptosis. p38 MAPK, a serine/threonine protein kinase often upregulated in cancer cells, plays a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6.NCI
code
  • C99134
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