About: Mericitabine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mericitabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mericitabine
UMLS_CUI
  • C2975145
CAS_Registry
  • 940908-79-2
FDA_UNII_Code
  • TA63JX8X52
Contributing_Source
  • FDA
Chemical_Formula
  • C18H26FN3O6
FULL_SYN
  • PSI 6130 DiisobutyrateSYNCI
  • 2' alpha-fluoro-2' beta-methyl-3',5'-diisobutyryldeoxycytidineSNNCI
  • MericitabinePTNCI
  • 3',5'-diisobutyryl PSI 6130SYNCI
  • R7128CNNCI
  • RG 7128CNNCI
  • RO-5024048CNNCI
  • MERICITABINEPTFDATA63JX8X52
  • 2'-deoxy-2'-fluoro-2'-c-methylcytidine DiisobutyrateSNNCI
DEFINITION
  • An orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor. After intracellular uptake, mericitabine is phosphorylated into two active triphosphate metabolites, which disable HCV RNA-dependent RNA polymerase (non-structural protein 5B; NS5B) upon binding. This results in the blockage of viral HCV RNA production and thus viral replication. This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly.NCI
code
  • C98959
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