About: Ebselen-containing Oral Capsule SPI-1005     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ebselen-containing Oral Capsule SPI-1005
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ebselen-containing Oral Capsule SPI-1005
NCI_META_CUI
  • CL432490
PDQ_Open_Trial_Search_ID
  • 714508
PDQ_Closed_Trial_Search_ID
  • 714508
FULL_SYN
  • Ebselen-containing Oral Capsule SPI-1005PTNCI
  • SPI-1005CNNCI
DEFINITION
  • An oral capsule containing a proprietary formulation of the organoselenium compound ebselen, with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation.NCI
code
  • C98398
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