About: GM-CSF-encoding Oncolytic Adenovirus CGTG-102     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • GM-CSF-encoding Oncolytic Adenovirus CGTG-102
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • GM-CSF-encoding Oncolytic Adenovirus CGTG-102
NCI_META_CUI
  • CL432405
PDQ_Open_Trial_Search_ID
  • 712555
PDQ_Closed_Trial_Search_ID
  • 712555
FULL_SYN
  • GM-CSF-encoding Oncolytic Adenovirus CGTG-102PTNCI
  • CGTG-102CNNCI
DEFINITION
  • A recombinant, oncolytic serotype 5/3 capsid-modified adenovirus encoding the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus enhances antigen presentation, promotes natural killer (NK) cell-mediated killing and causes a cytotoxic T cell (CTL) response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death. CGTG-102 is designed to replicate only in cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors. Replacement of the Ad5 capsid protein knob with a knob domain from serotype 3 causes higher transduction in cancer cells as compared to normal cells.NCI
code
  • C98287
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