About: Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine
NCI_META_CUI
  • CL432401
PDQ_Open_Trial_Search_ID
  • 712484
PDQ_Closed_Trial_Search_ID
  • 712484
FULL_SYN
  • Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell VaccinePTNCI
  • GVAX Melanoma VaccineSYNCI
DEFINITION
  • An allogeneic cancer vaccine composed of lethally irradiated whole melanoma cancer cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injections, allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.NCI
code
  • C98282
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