About: CCL21-expressing H1944 Cell Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CCL21-expressing H1944 Cell Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CCL21-expressing H1944 Cell Vaccine
NCI_META_CUI
  • CL432400
PDQ_Open_Trial_Search_ID
  • 712206
PDQ_Closed_Trial_Search_ID
  • 712206
FULL_SYN
  • CCL21-expressing H1944 Cell VaccinePTNCI
  • Recombinant Human 6C Cytokine-expressing H1944 Cell VaccineSYNCI
DEFINITION
  • A cancer cell vaccine comprised of the allogeneic human lung adenocarcinoma cell line H1944 that has been transduced ex vivo with adenoviral vector encoding human cytokine chemokine C-C motif ligand 21 (CCL21), with potential immunomodulating and antineoplastic activities. Upon administration, CCL21-expressing H1944 cell vaccine expresses the chemokine CCL21, which may induce an antitumoral cytotoxic T-lymphocyte immune response in the tumor microenvironment. CCL21 has been shown to attract antigen presenting cells (APCs), like leukocytes and DCs, and natural killer (NK) cells and their T-cell effectors to induce a cytotoxic immune response. H1944 cells contain tumor-associated antigens (TAAs) overexpressed in non-small cell lung cancer (NSCLC).NCI
code
  • C98281
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