About: Chloroquinoxaline Sulfonamide

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About: Chloroquinoxaline Sulfonamide Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Chloroquinoxaline Sulfonamide
rdfs:subClassOf	Topoisomerase-II Inhibitor nodeID://b658947 nodeID://b658948 nodeID://b658949 nodeID://b658950 nodeID://b658951 nodeID://b658952 nodeID://b658953
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Chloroquinoxaline Sulfonamide
NSC_Code	339004
UMLS_CUI	C0049111
CAS_Registry	97919-22-7
ALT_DEFINITION	A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41055
PDQ_Closed_Trial_Search_ID	41055
Legacy_Concept_Name	Chloroquinoxaline_Sulfonamide
FULL_SYN	ChlorsulfaquinoxalineSYNCI CQSPTNCI-GLOSSCDR0000044381 chlorosulfaquinoxalineSYNCI CQSABNCI Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-SNNCI Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-SYDTPNSC0339004 Chloroquinoxaline sulfonamideSYDTPNSC0339004 Chloroquinoxaline SulfonamidePTNCI chloroquinoxaline sulfonamidePTNCI-GLOSSCDR0000045331
DEFINITION	A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)NCI
code	C982
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0138400

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