About: MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide Vaccine
NCI_META_CUI
  • CL429828
PDQ_Open_Trial_Search_ID
  • 702861
PDQ_Closed_Trial_Search_ID
  • 702861
FULL_SYN
  • MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide VaccinePTNCI
DEFINITION
  • A combination peptide vaccine of 2 chimeric peptides of the promiscuous T cell epitope derived from measles virus fusion protein (MVF; amino acid residues 288-302) co-synthesized with B-cell epitopes derived from the HER-2/neu a.a. 597-626 and HER-2/neu a.a. 266-296, with potential antineoplastic activity. Vaccination with MVF-HER-2(597-626)/MVF-HER-2(266-296) peptide vaccine may be capable of inducing an active specific immune response, mounting a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress the HER-2 protein. The oncogenic protein HER-2, a member of the human epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in a variety of cancers and is correlated with increased tumor growth, progression and a poor prognosis. HER-2(597-626) corresponds to the binding site of trastuzumab on the extracellular domain IV of HER-2; HER-2 (266-296) corresponds to the binding site of pertuzumab on the dimerization loop of domain II of HER-2.NCI
code
  • C97344
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