About: Topical Wound Spray HP802-247     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Topical Wound Spray HP802-247
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Topical Wound Spray HP802-247
NCI_META_CUI
  • CL429687
PDQ_Open_Trial_Search_ID
  • 701416
PDQ_Closed_Trial_Search_ID
  • 701416
FULL_SYN
  • Topical Wound Spray HP802-247PTNCI
  • Allogeneic Keratinocyte/Fibroblast Topical Spray HP802-247SYNCI
  • HP802247CNNCI
  • HP802-247CNNCI
DEFINITION
  • A cell-based combination product consisting of a fibrinogen solution and a cell preparation containing allogeneic non-proliferating, living human skin-derived keratinocytes and fibroblasts, suspended in thrombin, with potential topical wound healing enhancing and topical anti-ulcer activity. Upon sequential spray of the two components of HP802-247 topically, a thin fibrin matrix is formed on the wound surface and the cellular components are capable of secreting wound healing cytokines and growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), granulocyte-macrophage colony-stimulating growth factor (GM-CSF) and keratinocyte growth factor. Cell concentration and keratinocyte-to-fibroblast ratio in HP802-247 are essential for optimal growth factor production and thus the efficacy of this agent.NCI
code
  • C97133
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