About: MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells
NCI_META_CUI
  • CL429642
PDQ_Open_Trial_Search_ID
  • 700454
PDQ_Closed_Trial_Search_ID
  • 700454
FULL_SYN
  • MAGE-A3 Reactive T Cell Receptor-transduced Autologous T CellsPTNCI
  • MAGE-A3 TCR-transduced Autologous T cellsSYNCI
DEFINITION
  • Human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176.NCI
code
  • C97035
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