About: Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine
NCI_META_CUI
  • CL429360
PDQ_Open_Trial_Search_ID
  • 698993
PDQ_Closed_Trial_Search_ID
  • 698993
FULL_SYN
  • Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope VaccinePTNCI
  • Recombinant Bordetella pertussis Adenylate Cyclase Toxin-Tyrosinase.A2 Epitope YMDGTMSQV VaccineSYNCI
DEFINITION
  • A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis.NCI
code
  • C96735
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