About: Estrogen Receptor Agonist GTx-758     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Estrogen Receptor Agonist GTx-758
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Estrogen Receptor Agonist GTx-758
NCI_META_CUI
  • CL429118
PDQ_Open_Trial_Search_ID
  • 698431
PDQ_Closed_Trial_Search_ID
  • 698431
FULL_SYN
  • Estrogen Receptor Agonist GTx-758PTNCI
  • GTx-758CNNCI
  • CapesarisBRNCI
DEFINITION
  • An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration.NCI
code
  • C96432
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