About: Cholecystokinin B Receptor Antagonist YF476     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cholecystokinin B Receptor Antagonist YF476
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cholecystokinin B Receptor Antagonist YF476
UMLS_CUI
  • C0535928
PDQ_Open_Trial_Search_ID
  • 698116
PDQ_Closed_Trial_Search_ID
  • 698116
FULL_SYN
  • Cholecystokinin B Receptor Antagonist YF476PTNCI
  • YF476CNNCI
  • CCK-B/Gastrin Receptor Antagonist YF476SYNCI
  • Cholecystokin 2 (CCK(2)) Receptor aAtagonist YF476SYNCI
DEFINITION
  • An orally active, benzodiazepine type, selective cholecystokinin B receptor (CCKBR; CCK2R; gastrin receptor) antagonist with potential gastric acid reducing and antiproliferative activity. Upon administration of YF476, this agent selectively binds to and blocks the CCKBR, thereby preventing the binding of gastrin and cholecystokinin. This may prevent gastric neuroendocrine enterochromaffin-like (ECL) cell-induced secretion of histamine, ultimately preventing gastric acid secretion from adjacent parietal cells. In addition, YF476 may inhibit ECL cell proliferation and ECL-derived gastric carcinoids.NCI
code
  • C96427
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