About: Anti-OX40 Monoclonal Antibody     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-OX40 Monoclonal Antibody
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Anti-OX40 Monoclonal Antibody
NCI_META_CUI
  • CL428374
PDQ_Open_Trial_Search_ID
  • 696645
PDQ_Closed_Trial_Search_ID
  • 696645
FULL_SYN
  • anti-OX40 MoAbABNCI
  • Anti-OX40 Monoclonal AntibodyPTNCI
DEFINITION
  • An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), anti-OX40 monoclonal antibody selectively binds to and activates the OX40 receptor. Receptor activation induces proliferation of memory and effector T lymphocytes. In the presence of tumor associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed by CD4 T cells and provides a costimulatory signal for T cell activation.NCI
code
  • C96040
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